AortaCell is focused on applying microcurrent via directing stem cells to repair aortic aneuyrsms.
How does it work? The microcurrent signal causes the weakened aortic wall tissue to release SDF-1, which is a stem cell homing signal, and stem cells than migrate from the patient’s own bone marrow, fat and circulating blood to the weakened area. After we have recruited enough repair cells we flip a switch on the microcurrent stimulator and the polarity is reversed and the voltage is dropped and we trigger the stem cells to form into smooth muscle. The end result is the previous thin aortic vessel wall is now thick strong and muscular with no risk of rupturing.
How may it be applied?
1. Total repair of small aortic aneurysms non-invasively by place the microcurrent signal generator above the area (outside the body like shinging a flashlight or how they do focal radiation therapy for cancer) to be treated. We may or may not have to place a negative electrode on the back of the patient.
2. Strengthening aortic necks to improve endoluminal stent graft long term sealing and to reduce risk of migration.
3. A different anti-angiogenic microcurrent signal may be used to non-invasively seal backflow collateral type endoleaks.
4. We can direct the microcurrent signal via an optical probe endovascular catheter to better ensure the pure right signal reaches the target aortic wall tissue for regeneration without the hinderance of calibrating for the fat, hair and other obstacles in the way of a pure to tissue signal with the non-invasive system. You may have seen John Simpson’s new startup is directing laser light up a post athrectomy catheter and PDA balloon to improves results of lower limb revascularization. We can do the same with our patented microcurrent signals which we believe will be more effective than laser light or ultrasound.
5. We can wrap a stent graft, or at least the proximal and distal necks, with a microcurrent bandage – like this one www.procellera.com. This will attract stem cells to graft material especially at the fixation sealing points.
6. We can coat graft material with an agent and then use the non-invasive microcurrent signaling to grow muscle up and down the graft material to strengthen and seal it. With this procedure you could reduce the entry profile of a stent graft with thinner materials and then build up the strength and sealing ability afterwards with non-invasive microcurrent treatments or by a 5FR optical probe microcurrent delivery catheter.
AortaCell TM = non-invasive microcurrent energy that in stage 1 causes a stem cell homing signal protein (SDF-1) to be released from stimulated aortic aneurysmal tissue (stem cells home to this focal stimulated tissue coming from the patients own bone marrow, fat tissue and circulating blood) and in stage 2 (reversed polarity and lower voltage) differentiates those recruited stem cells into smooth muscle thus strengthening the aortic wall back to healthy non-aneurysmal tissue sufficiently strong to eliminate continued expansion of the aneurysm. This method follows exactly the natural tissue regeneration method found in nature in all animals.