CerebraCell

cerebraCerebraCell is focused on brain regeneration utilizing patented microcurrent signals that home stem cells to the brain and cause new blood vessels to grow.  For advanced severe cases we add stem cell and growth factor injections and for extremely advanced cases we implant a re-fillable, programmable micro pump regeneration stimulator.

Product Description = Cerebracell is designed to stimulate true neurogenesis, the formation and nurturing of new neuron cells, to regenerate damaged or diseased brain tissue = true brain regeneration.  We do this by bioelectric stimulation controlled release of more than 10 essential brain regeneration promotion cytokines.  Our most important controlled cytokine release is SDF-1 which is a stem cell homing factor which recruits stem cells from a patient’s own bone marrow, fat and circulating blood to the stimulated brain tissue areas.  We have another signal of opposite polarity for controlling the differentiation of those recruited stem cells into healthy functioning brain tissue.  We also stimulate the release of IGF-1 for DNA level repair, HGF, EGF, Activin A+B, eNOS, VEGF, Follistatin and Tropoelastin all of which contribute to regeneration.  eNOS, HGF and VEGF help improve blood supply to the treated area.  For severe brain damage recovery and difficult disease cases we add our programmable micro infusion pump which is filled daily or weekly with our proprietary CCA-15 and CCR-15 fifteen component angiogenic and regeneration compositions comprised of a variety of cell types, growth factors, nutrient hydrogel, exosomes, Micro RNAs, brain matrix and other neurogenesis promoting molecules including harmine and tetrahydroharmine alkaloids and inflammation control agents We believe that our combination bioelectric regeneration stimulator, micro infusion pump and proprietary 15 component angiogenic + regeneration compositions have the potential to do a better job of helping people recover from brain injuries or brain related diseases than any other therapy brought forward before.  We are on a path to implement well designed clinical trials to prove this out.

For brain tumor cancer patients we have patent pending specially tuned bioelectric signals designed to stop cell division and blood supply to the tumors. 

CerebraCell is targeting these disease states and conditions:

  • Cerebral stroke recovery.
  • Concussion recovery.
  • Injury related brain damage.
  • Brain cancer recovery.
  • Parkinson’s.
  • Alzheimer’s and dementia.
  • Cerebral aneurysm repair.
  • Depression.
  • Brain memory recovery and enhancement.
  • Brain function enhancement.

Corporate Affairs:

CerebraCell operates as a subsidiary of Leonhardt Ventures (Leonhardt Vineyards LLC DBA Leonhardt Ventures).

Leonhardt Ventures

1531 6th Street, Unit 401

Santa Moncia, CA  90401

Office DIRECT 310 310 2534

Executive Chairman and CEO:  Howard J. Leonhardt – hleonhardt@aol.com

President and CSO:  Dr. King Liu – YKingLiu@uncm.edu,

Director of Marketing:  Brian Hardy – brian@fizzpopmedia.com

CerebraCell is duly incubating in the Cal-X Stars Business Accelerator, Inc. in collaboration with LABioHub and LABioMed in Santa Monica, California www.calxstars.com and Leonhardt’s Launchpads www.leonhardtslaunchpads.com at the University of Northern California Science and Technology Center in Rohnert Park, CA – http://www.uncm.edu/STIC.php  – University of Northern California, 1300 Valley House Dr, Suite # 100-27

Rohnert Park, CA 94928, (707) 664-6365

Investments in CerebraCell may only be made by verified accredited investors via investing in Cal-X Stars Business Accelerator, Inc. at this time –

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Postischemic IGF-1 Gene Transfer Promotes Neurovascular …

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SDF-1 

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Role of the SDF-1-CXCR4 axis in stem cell-based therapies for …

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The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12 …

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HGF

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Therapeutic potential of hepatocyte growth factor against cerebral …

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Acute hepatocyte growth factor treatment induces long-term …

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Hepatocyte growth factor (HGF) is an interesting candidate for acute stroke … (5 μg) after a 45-minutestroke, with regard to brain injury and neurologic recovery. …… in biological procedures relating to development and regeneration [3] [4].

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Follistatin

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Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting … – Stroke

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[Expression of follistatin, activin A and BMP-4 in rats with … – JoVE

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Oct 25, 2014 – Here we describe a protocol that has been optimized to recover these discs … At present, two major types of ischemic stroke models have been …

Activin 

Scientists identify main component of brain repair after stroke …

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National Institutes of Health

Oct 27, 2015 – Scientists identify main component of brain repair after stroke … “We found thatregeneration is a unique program in the brain that occurs after …

Biologists have found a gene that controls brain repair | ExtremeTech

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Oct 29, 2015 – Control of a single gene can stimulate partial regeneration after a damaging stroke, in both live mice and cultured human …

[PDF]

ACTIVIN A REDUCES BRAIN INJURY AFTER STROKE by SHIBANI S …

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Oct 17, 2008 – administration of activin A prior to stroke onset protected against ….. information on circuit reorganization and repair mechanisms …… growth and tubulogenic effects on endothelial cells necessary for hepatic regeneration.

Neuroregenerative strategies in the brain: emerging significance of …

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Sep 24, 2008 – aNeurogenesis and Brain Repair Group, Neurobiology Program, …. andneuroregeneration in animal models of brain injury and stroke (Chang et al. 2003 … BMP receptor II (BMPRII), activin receptor IIA (ActRIIA), and activin …

The roles of activins in repair processes of the skin and the brain.

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Mol Cell Endocrinol. 2001 Jun 30;180(1-2):169-77. The roles of activins in repair processes of the skin and the brain. Munz B(1), Tretter YP, Hertel M, Engelhardt …

Activin: a novel player in tissue repair processes. – NCBI

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Recent studies have demonstrated a strong expression of activin in repair … the skin, the lung, the intestine, the cardiovascular system, and even the brain.

Activin plays a key role in the maintenance of long-term memory and …

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Thus, the level of activin in the brain during the retrieval phase plays a key role in the … 1A), which eliminates the possibility that neuronal damage occurred.

VEGF 

Roles for VEGF in Brain Repair

https://expert.gwu.edu/display/doc-0d26a7a817d19069ccdf1018278813a1

Home · Organizations. Roles for VEGF in Brain Repair Conference Paper uri icon. Overview. authors. Janette M Krum. publication date. 2004. presented at event.

Role of vascular endothelial growth factor in neuronal DNA damage …

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National Center for Biotechnology Information

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JCI – VEGF: a critical player in neurodegeneration

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VEGF can also have favorable effects on the recovery of an ischemic brain insult. …. DNA damage andrepair in rat brain following a transient cerebral ischemia.

Neurotrophic Effects of Vascular Endothelial Growth Factor on …

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The Journal of Neuroscience

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for the first time, that VEGF is directly neurotrophic to CNS neurons in culture. …… revascularization and astroglial proliferation: roles for VEGF in brain repair.

VEGF overexpression induces post-ischaemic neuroprotection … – Brain

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Research progress of VEGF and brain injury repair mechanism

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Vernacular Title: VEGF与颅脑损伤修复机制的研究进展. Author: Keywo

Electrical Stimulation 

Stimulating brain with electricity ‘boosts stroke recovery’ – BBC News

www.bbc.com/news/health-35821286

BBC

Mar 17, 2016 – Stimulating the brain with electrical current can help improve recovery after a stroke, research from the University of Oxford suggests.

“Micro-Current Biotech” Therapy for Stroke Rehabilitation from WWC …

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LinkedIn

Dec 15, 2015 – Micro-Current Biotech” Therapy for Stroke Rehabilitation from WWC Probiotics, …TENS and later on MENS are used to take away pain of Diabetic … talk about strategy as if it’s some kind of high-brain scientific methodology.

Post-Stroke Treatment with Microcurrent and Acupuncture – YouTube

 5:17

https://www.youtube.com/watch?v=pL3C4GkI3Ho

May 29, 2013 – Uploaded by MicroLightVideos

Post-Stroke Treatment with Microcurrent and Acupuncture … of microcurrenttherapy, Microlight therapy …

Electrical brain stimulation could support stroke recovery: Hand and …

https://www.sciencedaily.com/releases/2016/03/160316151108.htm

Science Daily

Mar 16, 2016 – Applying an electric current to the brain can help recovery from stroke, Oxford University researchers have found. A team from Oxford’s Nuffield …

Electrical Stimulation Elicits Neural Stem Cells Activation: New … – NCBI

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National Center for Biotechnology Information

by Y Huang – ‎2015 – ‎Cited by 1 – ‎Related articles

Oct 19, 2015 – Keywords: electrical stimulation, neural stem cells, activation, … that endogenous NSCs can be a potential therapy for brain tissue repair.

Edmonton Neurotherapy: Non-Invasive Brain Stimulation …

www.edmontonneurotherapy.com/brain_stimulation_therapies.html

Information on non-invasive brain stimulation/neuromodulation technologies … for medical devices using microcurrent levels of electrical stimulation across the ….. within stroke rehabilitationprograms to enhance motor function re-learning.

Directing migration of human stem cells with electric fields …

https://www.cirm.ca.gov/…/directing-mi

California Institute for Regenerative Medicine

We will combine the electric stimulation with other treatment to establish a potent and … We aim to guide human stem cells to repair diseased or damaged tissues. … electric fields in the brain, which may guide migration of neural stem cells.

Electrical Stimulation of the Brain Boosts Birth of New Cells

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Society for Neuroscience

Animal study suggests deep brain stimulation improves memory … and Science, an expert on stem cells and brain repair who was unaffiliated with the study.

Developing stem cell-based therapies for neural repair:

https://books.google.com/books?isbn=2889194027

Clare Parish, ‎Lachlan Thompson – 2015

While the link between electrical stimulation of the human brain and neurogenesis awaits investigation, a phase I clinical trial assessing the effect of DBS .

Targeted brain stimulation aids stroke recovery in mice, scientists find …

https://med.stanford.edu/…/targeted-brain-sti

Stanford University School of Medicine

Aug 18, 2014 – Animal studies have indicated that electrical stimulation of the brain can improve … However, “existing brain-stimulation techniques activate all cell types in the …. Neural stem cellshelped repair stroke damage in rats’ brains.

Less-invasive method of brain stimulation helps patients with …

https://www.sciencedaily.com/releases/2012/10/121016103413.htm

Science Daily

Oct 16, 2012 – Electrical stimulation using extradural electrodes—placed … meaningful benefits for patients with Parkinson’s disease, according to new research.

FDA approves the treatment of brain tumors with electrical fields

www.gizmag.com/treatment-of-braintumors-with-electrical-fields/21433/

Gizmag

Feb 13, 2012 – The promising new non-invasive treatment by Novocure uses “Tumor Treating Fields” (NovoTTF) to treat cancerous growths and is now …

Electrical Scalp Device Can Slow Progression of Deadly Brain Tumors …

www.nytimes.com/…/electrical-scalp-device-can-slow-progressi…

The New York Times

Nov 15, 2014 – An electrical device glued to the scalp can slow cancer growth and prolong … with the deadliest type of brain tumor, glioblastoma, researchers have found. … So far, Novocure has been providing it free to patients without …

Bill Doyle: Treating cancer with electric fields | TED Talk | TED.com

 15:35

https://www.ted.com/…/bill_doyle_treating_cancer_with_ele

TED

With his company Novocure, Bill Doyle works to bring breakthrough medical …. Please show me any 2 brain …

This Electric Helmet Looks Goofy But It Zaps Deadly Brain Cancer

gizmodo.com/this-electric-helmet-looks-goofy-but-it-zaps-deadly-bra-1579…

Gizmodo

May 22, 2014 – This Electric Helmet Looks Goofy But It Zaps Deadly Brain Cancer · Sarah Zhang … It Zaps Deadly Brain Cancer. Images courtesy of NovoCure.

Electroacupuncture preconditioning reduces cerebral ischemic injury …

bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-13-22

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In addition, we investigated whether the expression of brain-derived … The expression of BDNF proteinincreased significantly from 6 h, reaching a plateau at 12 h … Focal cerebral ischemia Electroacupuncture BDNF SDF-1α Preconditioning … of 1 mA and a frequency of 2 Hz for 20 min using Grass S88 electro stimulator …

STEM CELLS 

Breakthrough in stem cell treatment for Parkinson’s – Medical News …

www.medicalnewstoday.com/articles/285069.php

Medical News Today

 Rating: 4.7 – ‎10 votes

Nov 7, 2014 – Researchers say it is possible to make dopamine

Fetal cells injected into a man’s brain to cure his Parkinson’s | New …

https://www.newscientist.com/…/dn27593-fetal-cells-injected-into-a-man…

New Scientist

May 26, 2015 – An experimental Parkinson’s treatment abandoned in the 1990s has been … and couldrestore a person’s control of their movement

Cell replacement therapy for Parkinson’s disease – ScienceDirect

www.sciencedirect.com/science/article/pii/S0925443908001993

ScienceDirect

by R Wijeyekoon – ‎2009 – ‎Cited by 54 – ‎Related articles

Of these embryonic stem cells and induced pluripotent stem cells seem the most …. has always been attractive for the treatment of any disorder including Parkinson’s … This patient had derived some clinical benefit from the graft for ∼ 4 years … functional recovery following intra-striatal transplantation of carotid body cell …

Neural stem cell transplants aid traumatic brain injury recovery …

www.eurekalert.org/pub_releases/2016-04/ctco-nsc041916.php

Apr 19, 2016 – Traumatic brain injury (TBI) is a major cause of mortality and morbidity, often causing lifelong disability for those who survive. When researchers …

Stem cells help repair traumatic brain injury by building ‘biobridge …

https://www.sciencedaily.com/releases/2013/10/131003111204.htm

Science Daily

Oct 3, 2013 – Stem cells help repair traumatic brain injury by building ‘biobridge’ … in the brain in need of repair, helping promote functional recovery from …

Can Stem Cells Help Restore Brain Function After Traumatic Injury …

www.perkinelmer.com/…/can-stemcells-help-restore-brain-functionality-…

PerkinElmer

Nov 7, 2014 – Research using human neural stem cells (hNSCs) is showing promise. … stem cells(hNSCs) to promote recovery of neural function after injury.

Stem cell therapy shows promise in repairing brain damage even …

stemcellstm.alphamedpress.org/site/misc/PressRelease032.xhtml

Stem cell therapy shows promise in repairing brain damage even hours after stroke … ensure complete recovery for stroke patients poses an extreme challenge, …

Siddharthan Chandran: Can the damaged brain repair itself? – TED.com

 15:57

https://www.ted.com/…/siddharthan_chandran_can_the_dam

TED

Feb 24, 2014

After a traumatic brain injury, it sometimes happens that the brain can repairitself, building new brain cells …

Electrical stimulation of cerebellar fastigial nucleus promotes the …

www.sciencedirect.com/science/article/pii/S0304394012006908

ScienceDirect

by B Liu – ‎2012 – ‎Cited by 11 – ‎Related articles

This study focused on the effects of electrical stimulation of cerebellar fastigial nucleus on the expression of growth arrest and DNA damage inducible gene β.

These results suggest that FN electrical stimulation can promote the expression of Gadd45β and motor function recovery after focal cerebral ischemia.

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Neuronal apoptosis in cerebral ischemia/reperfusion area following …

www.nrronline.org/article.asp?issn=1673

Neural Regeneration Research

by J Liu – ‎2014 – ‎Cited by 12 – ‎Related articles

May 29, 2014 – Results from the electrical stimulation group revealed that rats exhibited a …. TheDNA repair proteins, Ku70 and Ku80, are DNA-binding regulatory … Cytoplasmic Ku70 is involved in the control of cell apoptosis, specifically Bax-mediated apoptosis . …. Ku70 and Bax expressionfollowing fastigial nucleus

Neuronal apoptosis in cerebral ischemia/reperfusion area following …

www.nrronline.org/article.asp?issn=1673…

Neural Regeneration Research

by J Liu – ‎2014 – ‎Cited by 12 – ‎Related articles

May 29, 2014 – Results from the electrical stimulation group revealed that rats exhibited a …. TheDNA repair proteins, Ku70 and Ku80, are DNA-binding regulatory … Cytoplasmic Ku70 is involved in the control of cell apoptosis, specifically Bax-mediated apoptosis . …. Ku70 and Bax expressionfollowing fastigial nucleus

Biologists show bioelectrical signals control tumors arising from …

www.news-medical.net/…/Biologists-show-bioelectrical-signals-control-tumors-arising…

May 28, 2014 – “These distant bioelectric signals suppressed tumor growth, despite the cells’ … Prior News New fNIRS -FD instrument can identify affected areas of brain … Tecentriq drug gets FDA approval to treat urothelial carcinoma.

Electrical brain stimulation could support stroke recovery

medicalxpress.com › Neuroscience

Mar 16, 2016 – Applying an electric current to the brain can help recovery from … plus anodal tDCS compared to motor rehabilitation plus sham treatment.

Alzheimer’s Treatments

Electroacupuncture Treatment Improves Learning-Memory Ability – NCBI

www.ncbi.nlm.nih.gov/ 

 

National Center for Biotechnology Information

by J Jiang – ‎2015 – ‎Cited by 2 – ‎Related articles

Mar 3, 2015 – Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer’s Disease: …

Electroacupuncture Treatment Improves Learning … – ResearchGate

https://www.researchgate.net/…/274262088_Electroacupunctu  ResearchGate

Official Full-Text Publication: Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer’s …

New Alzheimer’s treatment fully restores memory function – ScienceAlert

https://www.sciencealert.com/new-alzheimer-s-treatment-fully-restores-m… 

Mar 18, 2015 – Of the mice that received the treatment, 75 percent got their memories back. … for Alzheimer’s – a disease that affects 343,000 people in Australia, and 50 … against bacteria, and stimulate the brain’s microglial cells to activate.

Acupuncture Rejuvenates Alzheimer’s Disease Patients – HealthCMi

www.healthcmi.com/…/1403-acupuncture-rejuvenates-alzheimer-s-diseas… 

Dec 8, 2014 – Electroacupuncture reduces brain plaque proliferation associated with Alzheimer’s disease and associated dementia. The researchers …

Therapeutic potential of neurogenesis for prevention and recovery …

www.ncbi.nlm.nih.gov/ 

 

National Center for Biotechnology Information

by RD Brinton – ‎2006 – ‎Cited by 100 – ‎Related articles

1. Curr Alzheimer Res. 2006 Jul;3(3):185-90. … neurogenesis for prevention and recovery from Alzheimer’s disease: allopregnanolone as … Brinton RD(1), Wang JM. … The discovery of neurogenesis in the adult brain and the regenerative … IGF1 and VEGF, in the microenvironment of the subgranular zone (SGZ) are prime ..

Higher Levels of IGF-1 Are Associated With a Decreased Risk of …

www.neurologyreviews.com/index.php?id=25318&tx_ttnews%5Btt 

Among a sample of participants from the Framingham study, high levels of IGF1 are linked to a lower risk of Alzheimer’sdisease and subclinical brain atrophy. SAN DIEGO—Dementia-free patients with high levels of insulin-like growth factor 1 (IGF1) show a lower risk of …

Alzheimer’s disease in men linked to low levels of hormone IGF-1 …

https://www.sciencedaily.com/releases/…/121002091759.ht 

 

Science Daily

Oct 2, 2012 – Low serum levels of insulin-like growth factor-1 (IGF1) and … Link Between Brain Insulin Resistance, Neuronal Stress in Worsening Alzheimer’s Disease. June 26 … Hormone Improves Long-Term Recovery from Stroke, Study …