EarCell

bioEarCell is a startup within the Leonhardt Ventures Cal-X Stars Business Accelerator and Leonhardt’s Launchpads Utah focused on hearing loss recovery via regeneration. 

The company utilizes bioelectric stimulation to control release of specific proteins on demand for specific regenerative purposes in sequence:

1. SDF-1 (stem cell homing factor – recruits a persons own stem cells to stimulated tissues).

2. VEGF (for new blood vessel growth).

3  IGF-1 (for DNA repair at the nucleus level). 

4. Follistatin (for muscle and tissue regeneration).

5. RANKL (for demineralization and tissue loosening when needed).

6. Hepatocyte Growth Factor  (tissue regeneration)

7. eNOS (for dilating blood vessels for increasing flow).

8.  Tropoelastin (increases elasticity of any tissues such as skin, arteries, aorta, heart and promotes healing of wounds). 

9. Activin B (regeneration).

10.  GDF-10 and 11 (regeneration).

11.  EGF – epidermal growth factor (regeneration).

12.  FGF – fibroblast growth factor (regeneration).

In extreme cases we combine our regeneration microstimulator with an implantable, programmable, re-fillable stem cell/growth factor micro pump.

In cases of ear cancer we have special signals to stop tumor cell division and blood supply followed by the above regeneration protocol. 

Related Articles

General

Human Hearing Loss Could Be Reversible – The Atlantic

www.theatlantic.com/health/archive/2016/07/hearingloss…/491777/

The Atlantic

Jul 19, 2016 – Many animals regenerate the tiny hair cells that enable hearing—and there are promising signs that people can be made to do the same.

Future Regenerative Therapies for Hearing Loss: Your Questions …

https://hearinglosscure.stanford.edu/2012/08/future_regenerative_therapies_a_qa/

May 13, 2016 – As such, we thought that readers might find it helpful to have questions about possible future regenerative therapies for hearing loss, answered …

SDF-1

Inner ear cell therapy targeting hereditary deafness by activation of …

www.ncbi.nlm.nih.gov/…/PMC43072

National Center for Biotechnology Information

by K Kamiya – ‎2015 – ‎Cited by 3 – ‎Related articles

Jan 27, 2015 – … were found to be a key regulator for stem cell recruitment to the cochlear tissue. … Keywords: hereditary deafnessstem cell homing, mesenchymal stem cell, inner … (CCR2, CXCR4) in culture dish by the treatment of MCP-1 or SDF1. … inner ear cell therapy for recovering hearing in hereditary deafness.

Role of Stromal Cell-Derived Factor-1 Expression in the Injured Mouse …

www.ncbi.nlm.nih.gov/…/PMC40784

National Center for Biotechnology Information

by LA Kilpatrick – ‎2011 – ‎Cited by 5 – ‎Related articles

Sep 23, 2011 – SDF1 mRNA expression in normal and ouabain-treated ears was examined ….regeneration or repair after injury; moreover, optimizing SDF1 …

Study reveals how to regenerate mouse ears without … – Medical Xpress

medicalxpress.com › Genetics

Nov 2, 2015 – Study reveals how to regenerate mouse ears without a scar … Blocking Sdf1 function with a drug or by mouse genetics enhanced tissue …

A topical gel that can reverse sudden hearing loss – io9

io9.com/5698870/a-topical-gel-that-can-reverse-middle-age-hearingloss

io9

Nov 25, 2010 – The rapid onset of deafness in one ear is often part of a condition called “sudden sensorineural hearing loss” (SSHL for short). Though there …

Regenerative biology: How mice regrow ear tissue : Nature : Nature …

www.nature.com/articles/527136d

Nature

Nov 12, 2015 – Regeneration. Blocking a specific cell-signalling … A compound that inhibits the signalling between Sdf1 and these white blood cells enhanced scar-free regrowth of ear tissue in 

IGF-1

Growth factor-eluting cochlear implant electrode: impact on residual …

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-014-0280-4

by YS Kikkawa – ‎2014 – ‎Cited by 5 – ‎Related articles

Oct 4, 2014 – CI electrode analogs were coated with IGF1- or HGF-containing … Bioelectricalpotentials were recorded using subdermal stainless steel …

IGF-1 and Hearing Loss/Inner Ear Disorders – Nutronics Labs

www.nutronicslabs.com/igf1-and-hearingloss-inner-ear-disorders/

Aug 28, 2014 – IGF1 and Hearing Loss/Inner Ear Disorders. If you’re familiar with Nutronics Labs’ products, you know that IGF1 is the major protein naturally …

Topical Gel Shows Potential As Hearing Loss Treatment – Hearing …

www.hearingreview.com/2010/…/topical-gel-shows-potential-as-hearingloss-treatme…

Dec 16, 2010 – “The results indicated that the topical IGF1 application using gelatin … application results in hearing recovery in some patients with SSHL,” …

Novel therapy for hearing loss: Delivery of insulin-like growth factor 1 …

https://www.researchgate.net/…/6134522_Novel_therapy_for_hearing_loss ResearchGate

Novel therapy for hearing loss: Delivery of insulin-like growth factor 1 to the cochlea … Prognostic impact of salvage treatment on hearing recovery in patients with … performed a single-armed, prospective clinical trial of topical IGF1 therapy in …

Hearing Recovery by Local IGF1 Therapy in Sudden Deafness

oto.sagepub.com/content/145/2_suppl/P214.4.abstract

Abstract. Objective: Evaluate hearing recovery following local application of insulin-like growth factor 1 (IGF1) in patients with sudden sensorineural hearing loss …

Application of insulin-like growth factor-1 in the treatment of inner ear …

www.ncbi.nlm.nih.gov/…/PMC41599

National Center for Biotechnology Information

by N Yamamoto – ‎2014 – ‎Cited by 10 – ‎Related articles

Sep 10, 2014 – Insulin-like growth factor-1 (IGF1) is one of the growth factors that are … It includes age-related hearing loss, noise-induced hearing loss, …

HGF

The discovery of Hepatocyte Growth Factor (HGF) and its significance …

www.ncbi.nlm.nih.gov/…/PMC30811

National Center for Biotechnology Information

by T NAKAMURA – ‎2010 – ‎Cited by 182 – ‎Related articles

The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology …. Liverregeneration is recognized as an example of controlled tissue growth. …… cDNA restored hearing loss, the most prevalent sensory deficit in humans.

Local application of hepatocyte growth factor using gelatin hydrogels …

www.tandfonline.com/doi/pdf/10.1080/00016480902725197

by T Inaoka – ‎2009 – ‎Cited by 21 – ‎Related articles

attenuates noise-induced hearing loss in guinea pigs … containing hepatocyte growth factor (HGF) in protecting cochlear hair cells from noise-induced damage.

Hepatocyte growth factor mimetic protects lateral line hair cells … – NCBI

www.ncbi.nlm.nih.gov/…/PMC43091

National Center for Biotechnology Information

by PM Uribe – ‎2015 – ‎Related articles

Jan 28, 2015 – Hepatocyte growth factor mimetic protects lateral line hair cells from … Keywords: zebrafish, hair cell protection, hearing loss, aminoglycosides, hepatocyte …… Neomycin-induced hair cell death and rapid regeneration in the …

FGF

New findings hint toward reversing hearing loss | The Source …

https://source.wustl.edu/2015/07/new-findings-hint-toward-reversing-hearingloss/

Jul 15, 2015 – Unlike birds and amphibians, mammals can’t recover lost hearing. … The absence of certain FGF signals during inner ear development results …

Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell …

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0157768

by SG Lee – ‎2016

Jun 28, 2016 – Both MYC and FGF are activated in chick hair cell regeneration. Using a … or through induction after hair cell loss, leading to hearing recovery.

Sensory hair cell development and regeneration: similarities and …

dev.biologists.org/content/142/9/1561

Development

by PJ Atkinson – ‎2015 – ‎Cited by 15 – ‎Related articles

(A) No sensory hair cell regeneration occurs in the adult mouse cochlea. …. FGF also regulates the later stages of inner ear development and hair cell formation: …

EGF

Hair cell regeneration: winging our way towards a sound future

depts.washington.edu/rubelab/personnel/winging.pdf

University of Washington

by O Bermingham-McDonoghà – ‎2003 – ‎Cited by 111 – ‎Related articles

The discovery of hair cell regeneration in the inner ear of birds provides new optimism … molecular events, such as growth factors and signalling systems. We examine some of ….. factor α (TGFα) andepidermal growth factor in the presence of …

Hair cell regeneration: An exciting phenomenon . . . But will restoring …

www.rehab.research.va.gov/jour/05/42/4suppl2/matsui.html

Jan 27, 2006 – Abbreviations: EGF = epidermal growth factor, Math1 = mammalian atonal … hearingand balance deficits in humans due to loss of or damage to these cells. ….. Functional recovery in the avian ear after hair cell regeneration.

Activin

Activin potentiates proliferation in mature avian auditory … – NCBI

www.ncbi.nlm.nih.gov/…/20071511 National Center for Biotechnology Information

by JS McCullar – ‎2010 – ‎Cited by 15 – ‎Related articles

Jan 13, 2010 – … to an inability to regenerate sensory hair cells lost to inner ear trauma. … Conversely, addition of activin A, an Acvr2a/b ligand, potentiates …

Harvard researchers regenerate sound-sensing cells of mice with …

hsci.harvard.edu/…/harvard-researchers-regenerate-sound-sensing-…

Harvard University

Feb 21, 2014 – Despite years of evidence indicating that ear sensory cells do not … new hair cellregeneration strategies to treat hearing loss and deafness.

Follistatin

The molecular basis of neurosensory cell formation in ear … – NCBI

www.ncbi.nlm.nih.gov/…/PMC39015

National Center for Biotechnology Information

by B Fritzsch – ‎2006 – ‎Cited by 101 – ‎Related articles

… increasing likelihood of neurosensory hearing loss with age, thus depriving ….. GDF11 and follistatin determine the expression level of the cyclin-dependent …

‘Mighty mice’ made mightier – News Medical

www.news-medical.net/news/2007/08/29/29233.aspx

Aug 29, 2007 – If follistatin was increasing muscle growth solely by blocking myostatin, then … Researchers discover gene linked to age-related hearing loss.

Stem Cells + Growth Factors

Major step toward treatment for a leading form of hearing loss …

hsci.harvard.edu/major-step-toward-treatment-leading-form-hearin

Harvard University

“We show that hair cells can be generated in a damaged cochlea and that hair cell replacement leads to an improvement in hearing.”. … Sensorineural hearing loss is the most common form and is caused by the loss of sensory hair cells in the cochlea. … Auditory hair cell replacement …

Recent progresses in stem cell research and hearing restoration

www.sciencedirect.com/science/article/pii/S1672293008500018

ScienceDirect

by Y Hua – ‎2008 – ‎Related articles

Dec 17, 2014 – Hair cell regeneration is one of the essential steps for total hearing … or basic fibroblastgrowth factors, the number of sphere shaped cells ….. Mesenchymal stem cell transplantation accelerates hearing recovery through the …

Hair cell regeneration: An exciting phenomenon . . . But will restoring …

www.rehab.research.va.gov/jour/05/42/4suppl2/matsui.html

Jan 27, 2006 – The most commonly cited growth factors used to promote hair cell regeneration … Recently, the use of stem cells to repair damaged neurons or prevent ….. Functional recovery in the avian ear after hair cell regeneration.

Growth hormone helps repair the zebrafish ear — ScienceDaily

https://www.sciencedaily.com/releases/2011/09/110902083737.htm

Science Daily

Sep 5, 2011 – But, since a strong inflammatory response to tissue damage can interfere with wound … New Findings Hint Toward Reversing Hearing Loss.

New treatment options for hearing loss : Nature Reviews Drug …

www.nature.com/nrd/journal/v14/n5/abs/nrd4533.html

Nature

by U Müller – ‎2015 – ‎Cited by 16 – ‎Related articles

Mar 20, 2015 – Moreover, approaches that are based on stem cells and gene …. bFGF, basic fibroblastgrowth factor; BMP, bone morphogenetic … L. Hearing loss prevalence and risk factors among older adults in the ….. Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.

Stem Cells Point Toward a Treatment for Hearing Loss – EarQ

https://www.earq.com/news/stemcells-treatment-hearingloss

Researchers at the Indiana University School of Medicine have found a possible way of growing inner-ear hair cells, which allow one to hear and control …

The potential of stem cells for the restoration of auditory function in …

www.ncbi.nlm.nih.gov/…/PMC38025

National Center for Biotechnology Information

by Z Hu – ‎2013 – ‎Cited by 13 – ‎Related articles

The challenge in hearing regeneration & stem cell opportunity … Sensorineural hearing loss is a result of dysfunction of the inner ear cochlea. … One potential therapeutic approach is to replace damaged hair cells and SGNs with stem ….. Electrical stimulation of the midbrain for hearingrestoration: insight into the functional .

Electrical Stimulation

Taming Tinnitus with Electrical Stimulation – MIT Technology Review

https://www.technologyreview.com/…/taming-tinnitus-with-e

MIT Technology Review

May 24, 2010 – Stimulating the vagus nerve may help block phantom sounds by reorganizing the … Most often associated with hearing loss, it has become an …

Direct Electrical Stimulation of the Brain for Tinnitus Relief

https://www.tinnitusformula.com/…/direct-electricalstimulation-of-the-brain-for-tinnit…

Electrical stimulation of the brain has been used for many years and can offer … It was discovered these implants also reduced tinnitus due to hearing loss. … Upon recovering from surgery, at the first post-operative visit, the selection of the .

Electrical Stimulation Allows Gene Therapy to Restore Auditory …

www.medgadget.com/…/electricalstimulation-allows-gene-therapy-to-rest…

Medgadget

Apr 24, 2014 – Electrical Stimulation Allows Gene Therapy to Restore Auditory Nerves, … The resulting BDNF expression stimulated regeneration of spiral ganglion … Breakthrough: scientists useear implants to regrow auditory nerves.

Electric stimulation complements functional residual hearing in partial …

www.ncbi.nlm.nih.gov/…/20105110 National Center for Biotechnology Information

by R Podskarbi-Fayette – ‎2010 – ‎Cited by 26 – ‎Related articles

Acta Otolaryngol. 2010 Aug;130(8):888-96. doi: 10.3109/00016480903567189. Electric stimulationcomplements functional residual hearing in partial deafness.