“Cutting in Half Dental Brace and Aligner Wearing Time with Bioelectric Stimulation”
Orthodontic braces and clear aligners work by applying force to teeth in order to gradually realign them. This force causes a demineralization (softening) of the bone, which allows the tooth to move. Although the time it takes for patients to wear braces or aligners varies considerably, it generally takes on average about 2 years. To help shorten treatment time, Dr. John Marchetto of Weston, FL and Howard Leonhardt of Salt Lake City, UT has formed OrthodontiCell (Salt Lake City, Utah). OrthodontiCell has developed the Tooth Movement Accelerator TM, which uses bioelectric energy to significantly increase the rate at which teeth move. The Tooth Movement Accelerator TM is a removable and non-invasive appliance that a patient wears in the mouth for 40 minutes every 3 days. OrthodontiCell is working with Dr. Jorge Genovese of Argentina (also a co-founder) and is about to commence large animal studies utilizing the bioelectric energy. This will then be followed by applying the device in controlled clinical trials in the USA.
The technology is based on patent pending bioelectric stimulation technology originally developed to regenerate damaged hearts back in 1999 and is now adapted and reprogrammed for reducing orthodontic treatment time. The OrthodontiCell Tooth Movement Accelerator TM emits small electric pulses that controls expressions of RANKL, SDF-1, HGF, IGF-1, VEGF, eNOS and M-CSF as well as stem cell differentiation. Studies have been completed for all these cells and proteins individually for various applications of regeneration. Previously, a number of studies have demonstrated that regular needle injections of RANKL in the area of desired tooth movement, significantly accelerates tooth movement and decreases the time needed to wear braces or aligners.
This bioelectric stimulator, will achieve much faster orthodontic treatment results with less pain, in fact, the electrical stimulation actually has a pain reducing affect. When compared to the well documented tooth movement acceleration approach of using surgical corticotomies, it was faster while removing any morbidity along with eliminating the pain and suffering of surgery. The key to the increased rate is drawing an abundance of the needed cells and proteins to the site of tooth movement to accelerate the demineralization (softening) and re-mineralization (hardening) of bone, thereby allowing teeth to move faster. One example is SDF-1, a key patented signal for homing stem cells from the surrounding tissue (bone marrow, gum tissue, fat cells and circulating blood) to come to the treated site to aide in tooth movement. There are many other cells and proteins and cytokines that have an increased expression through specific patented signals, all working to substantially increase the rate of tooth movement.
Howard J. Leonhardt the Founder and CEO of Leonhardt Ventures and Cal-X Stars Business Accelerator, Inc., Dr. John Marchetto an Orthodontist in Weston, Florida and Dr. Jorge Genovese a collaborative researcher from Buenos Aires, Argentina are co-inventors of this product.
“This invention addresses the desire to reduce in half the time it takes to treat orthodontic patients. The approach is to speed up the normal process of bone demineralization in order to accelerate tooth movement. Millions of people that wear braces or aligners would love to cut their treatment time in half. Other light and vibration devices fall short in providing a clear and reliable pathway to the underlying mechanism of action for tooth movement. Also, the repeat RANKL needle injection methods are painful for the patients and are needed too frequently. This invention is completely different than previous devices as it provides clear cut direct control for the release of essential cells and proteins needed for accelerating tooth movement, and with less pain”, states Dr. John Marchetto, co-Inventor.
Link to news release…
Device to Cut Orthodontic Treatment Time in Half …
20th, 2016 – PRBuzz – Leonhardt Ventures — a developer, manufacturer and … OrthodontiCell is incubating within Cal-X Stars Business Accelerator, Inc. The …
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