BladderCell

bioBladderCell is a startup within the Leonhardt Ventures Cal-X Stars Business Accelerator and Leonhardt’s Launchpads Utah focused on bladder regeneration.

The company utilizes bioelectric stimulation to control release of specific proteins on demand for specific regenerative purposes in sequence:

1. SDF-1 (stem cell homing factor – recruits a persons own stem cells to stimulated tissues).

2. VEGF (for new blood vessel growth).

3  IGF-1 (for DNA repair at the nucleus level). 

4. Follistatin (for muscle and tissue regeneration).

5. RANKL (for demineralization and tissue loosening when needed).

6. Hepatocyte Growth Factor  (tissue regeneration)

7. eNOS (for dilating blood vessels for increasing flow).

8.  Tropoelastin (increases elasticity of any tissues such as skin, arteries, aorta, heart and promotes healing of wounds). 

9. Activin A + B

In extreme cases we combine our regeneration microstimulator with an implantable, programmable, re-fillable stem cell/growth factor micro pump.

In cases of bladder cancer we have special signals to stop tumor cell division and blood supply followed by the above regeneration protocol. 

BladderCell 

Leonhardt’s Launchpads Utah

489 E, 400 South, Unit 116

Salt Lake City, UT  84111

email:  hleonhardt@aol.com

Contact:  Howard J. Leonhardt 

RELATED SCIENTIFIC ARTICLES:

SDF-1

Search Results

[PDF]

272 involvement of sdf-1 in recruitment of alpha smooth muscle actin

www.ics.org/Abstracts/Publish/106/000272.pdf

International Continence Society

Trials on the urinary bladder regeneration by acellular grafts have not always … stromal cell-derived factor 1 (SDF1) in bladder muscle regeneration in in vitro …

[PDF]

bladder smooth muscle cell

www.ics.org/Abstracts/Publish/…/000272_poster.pdf

International Continence Society

by M Imamura – ‎Related articles

SDF1 could be a pivotal signal for inducing the inflammatory phase of bladder regeneration through migration of myofibroblast-like cells into the graft.

In situ tissue regeneration through host stem cell recruitment

www.nature.com/emm/journal/v45/n11/full/emm2013118a.html

Nature

by IK Ko – ‎2013 – ‎Cited by 40 – ‎Related articles

Nov 15, 2013 – In situ tissue regeneration utilizes the body’s own regenerating capacity by ….. In an attempt to protect SDF1α effects from endogenous inhibitors, ….. Bladder acellular matrix graft in rats: its neurophysiologic properties and …

HGF

In vitro comparative evaluation of recombinant growth factors for tissue …

www.ncbi.nlm.nih.gov/…/24095026

National Center for Biotechnology Information

by B Yang – ‎2014 – ‎Cited by 12 – ‎Related articles

Aug 15, 2013 – In vitro comparative evaluation of recombinant growth factors for tissue … the effects of various recombinant growth factors on bladder regeneration and … hepatocyte growth factor (HGF), and transforming growth factor beta 1 …

IGF-1

Engineered insulin-like growth factor-1 for improved smooth … – NCBI

www.ncbi.nlm.nih.gov/…/22014943

National Center for Biotechnology Information

by KM Lorentz – ‎2012 – ‎Cited by 18 – ‎Related articles

Oct 19, 2011 – Insulin-like growth factor-1 (IGF1) has been shown to induce potent … Recombinant Proteins/metaboli

Functional rat bladder regeneration through xenotransplantation of the …

onlinelibrary.wiley.com › … › Vol 81 Issue 4 › Abstract

John Wiley & Sons

by HJ PIECHOTA – ‎1998 – ‎Cited by 73 – ‎Related articles

Dec 25, 2001 – In addition, the contractility of the BAMG-regenerated bladders was examined with in vitro electrical and pharmacological stimulation …New Drugs Will Ignite Bladder Cancer Treatment …

https://healthcare.globaldata.com/…/trio-of-exciting-new-drugs-will-ignite-bladder-ca…

Jan 14, 2016 – The bladder cancer treatment market is set to boom from an estimated … The company’s latest report* states that the growth, which will occur across the … Heart Failure Market to 

Electrical stimulation to vagina muscle cells and rabbit bladder muscle …

www.researchgate.net/…/261059642_Electrical_stimulation_to_vagina_mu… ResearchGate

Publication » Electrical stimulation to vagina muscle cells and rabbit bladder muscle … Article:Electrical stimulation promotes motoneuron regeneration without …

Role of electrical stimulation for rehabilitation and regeneration after …

www.ncbi.nlm.nih.gov/…/PMC25274…

National Center for Biotechnology Information

by S Hamid – ‎2008 – ‎Cited by 113 – ‎Related articles

Aug 2, 2008 – Electrical stimulation in the form of functional electrical stimulation (FES) can …bladder or bowel functions by applying a controlled electrical …

Electrical Stimulation for Urinary Incontinence in Women: A Systematic …

www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382013000400454

by L Schreiner – ‎2013 – ‎Cited by 28 – ‎Related articles

… severity of coronary artery disease and severity of erectile dysfunction? author index … Intravaginalelectrical stimulation showed effectiveness in treating urge urinary ….. (ICS) joint report on the terminology for female pelvic floor dysfunction. …. 6690 / 612, Centro Clínico, Jardim Botânico, Porto Alegre, 90610-001, Brazil, …

Human amniotic fluid stem cell injection therapy for urethral sphincter …

by BS Kim – ‎2012 – ‎Cited by 43 – ‎Related articles

Aug 21, 2012 – Recently, human amniotic fluid stem cells (hAFSCs) have been proposed as an ideal … Nerve regeneration and neuromuscular junction formation of injected …… tracking of human amniotic fluid stem cells in the mouse heart.