30 startups | 12 are entering clinical stage of development now
1 with published clinical data.
Heart & Cardiovascular
Team that developed leading cardiovascular stent graft, first percutaneous heart valve and first heart stem cell therapy has developed 8 cardiovascular and heart-related organ regeneration startups. Second Heart Assist expects is set to complete first-in-man study in up to 30 pts by early summer and to exit by the end of the year. Only competitor on USA market now is at a $12 billion valuation. Vascustim is entering new clinical studies for diabetic ulcer treatment following pilot studies in Mexico. PressureStim is planning clinical studies for blood pressure management in Asia. AortaCell is ready to launch aorta regeneration large animal studies at U Virginia – core team previously captured world leadership in endovascular aorta repair. BioLeonhardt completed a small animal study at U of Utah and is now moving to large animal studies at Texas Heart Institute for total heart regeneration.
Major Organ Regeneration
12 startups focused on major organ regeneration. OrthoStim is entering clinical studies for knee and joint recovery. BladderCell is entering clinical studies in Brazil and has initiated a collaboration with independent group that already complete a successful study in children also in Brazil. The incontinence market is valued at over $4 billion with no full recovery solutions at this time. EyeCell completed a grant supported eye regeneration animal study in Utah and working with Dr. Laurie Chaikin and Dr. Ed Kondrot has data published on more than 176 patents. LiverCell is preparing for animal studies. KidneyCell working with collaborators in Brazil has a 21 patient clinical study published and is planing a new study. The other startups are in development stage. BioLeonhardt Whole Body is designing a whole body regeneration chamber, a womb for adults, and is filing a National Science Foundation Small Business Innovation Research grant application.
Cosmetic & Personal Care
7 startups all at clinical stage of development. MyoStim ED published first study this summer with 85% success compared to 0% for placebo group in treating erectile dysfunction. A 2nd study was published with 23 patients post surgical prostrate removal with success rates up to 50%. A new ED study with more signals is completed enrollment in May with target of 100% in target treatment group. HairCell launched clinical trials in South Africa targeting 30% improvement of hair density. Samumed a San Diego based competitor reached $12 billion valuation for 10% hair density improvement. TestiStim has patent issued and pilot data for testosterone management. SkinStim launched clinical trials in the South Africa and is preparing to launch at additional sites. DentaCell has data from numerous centers and is developing a full product pipeline. OrthodontiCell believes it can reduce time for straightening teeth by 2/3rds and keep teeth straight after straightening and his clinical trials now. Align Technology the leading competitor reached $30.9 billion valuation last year. Orthodonticell has enrolled 37 patients in its pilot clinical trial so far and expects data ready for publication by the end of fall 2019. Stem Cell Bra is launching clinical trials in South Africa after achieving 20% to 30% breast fullness volume increase in 4 weeks of treatment in 15 large animals.
CerebraCell is preparing for non-invasive clinical studies for brain injury recovery and memory improvement.
CancerCell is entering animal studies for bioelectric cancer treatment at UCLA. 140 patent claims are issued via Schuler patent option and 20 more pending from direct Leonhardt et al. filings. Patents for reading cancer tumors and custom delivering therapies. Pulse Biosciences and Novocure recently reached $500 million and $4.3 billion valuations respectively with their bioelectric cancer therapies after publishing positive pilot clinical study results. Autemedical from Brazil has also published positive clinical data for electromagenetic field cancer therapies which helps build excitement for this direction.
Estimated Startup Exit Schedule
2019 Portfolio Class
Current as of May 15th, 2019 CEO Ranking
Expected Startup Ripe for Exits Schedule (Highly Subject to Change)
1. EarCell www.ear-cell.com
2. Vascustim www.vascustim.com
3. Biopace https://leonhardtventures.com/bio-pace/
4. VibroCell https://leonhardtventures.com/vibrocell/
5. BioLeonhardt Whole Body and BodStim https://leonhardtventures.com/bioleonhardt-whole-body/
6. RegenaLung https://leonhardtventures.com/regenalung/
On deck circle working through the CalXelerartor www.calxelerator.com 108 day create to great program to be considered to be added to portfolio once an opening is available includes: PolypStim www.polypstim.com, AddictiStim, MemoryStim, MigraineStim, NerveStim, CraveStop, PainStim, LymphStim, BoneStim, SnoreStim, AirwayStim, GingavaStim, InfectiStim, DetoxStim.
$15 million Use of Proceeds
($1,500,000 already raised as of May 2019)
- About $3,000,000 to get get all 30 products patented, developed and through animal studies
- About $11,750,000 to get all 30 products through first-in man studies of about 20 to 30 patients each which leaves prime ripe for potential strategic partnership opportunity when considering likely insider voluntary re-investments from first exits if more funding is needed.
By product groups:
- Heart & Cardiovascular (9) = $6,000,000 which includes up to $2.3 million to Second Heart Assist, Inc.
- Brain (1) = $1,000,000
- Cosmetic & Personal Care (6) = $2,000,000
- Major Organ Regeneration (11) = $2,000,000
- Cancer (1) = $1,000,000
- Regenerative Economy (3) = $250,000
- Offering Cost and General Overhead Expenses = $1,500,000+
Innovation & Startup Accelerator Capsule Update May 19th, 2019
Development Pipeline Accelerator – Organized By Single Click Product Groups
Regenerative Medtech Portfolio 2019 Easy Logo Click Layout
2019 Portfolio Organized by Product Groups with Easy Click to Web Pages
Business model = accelerate 6 startups each year through first-in-man results and opportunity to seek strategic partner/buyer each year for the next 5 years. Goal is 23X ROI on accelerator shares and 63X on individual startup shares after 5 years.
Investment into the accelerator is 2:1 meaning if an investor invests $30,000 they get $30,000 worth of accelerator shares and also at no additional charge warrant to acquire by Dec. 31 of the year they invested also $30,000 worth of individual startup shares within the accelerator of their choice. They can choose to allocate $1000 each in 30 startups by example, $10,000 each in three startups or all $30,000 of their warrant into their single favorite startup.
Note – By charter we are limited to 30 startups in our accelerator in any given annual portfolio class. In short durations where we may have more than 30 startups we are working towards a merger, sale or a cut to reduce back down to 30. In the case of DentaCell Accelerator we have an accelerator within the accelerator which expands the total number of startups under this sub-accelerator. We are considering merging now VibroCell assets into either Second Heart Assist, Inc. or BioLeonhardt as an example.
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