RegenaLung

bioRegenaLung is a startup within the Leonhardt Ventures Cal-X Stars Business Accelerator and Leonhardt’s Launchpads Utah focused on lung regeneration.

The company utilizes bioelectric stimulation to control release of specific proteins on demand for specific regenerative purposes in sequence:

1. SDF-1 (stem cell homing factor – recruits a persons own stem cells to stimulated tissues).

2. VEGF (for new blood vessel growth).

3  IGF-1 (for DNA repair at the nucleus level). 

4. Follistatin (for muscle and tissue regeneration).

5. RANKL (for demineralization and tissue loosening when needed).

6. Hepatocyte Growth Factor  (tissue regeneration)

7. eNOS (for dilating blood vessels for increasing flow).

8.  Tropoelastin (increases elasticity of any tissues such as skin, arteries, aorta, heart and promotes healing of wounds). 

9. Activin A + B (regeneration)

10.  EGF.

In extreme cases we combine our regeneration micro stimulator with our patented implantable, programmable, re-fillable stem cell/growth factor micro pump – www.fluidsynchrony.com 

In cases of lung cancer we have special signals to stUS07775968-20100817-D00010op tumor cell division and blood supply followed by the above regeneration protocol – http://mysocialgoodnews.com/leonhardt-ventures-cerebracell-file-patent-application-bioelectric-signals-halt-tumor-growth-regenerate-organs/

We also have a subsidiary Regenalung COPD to address COPD. 

Corporate Information:

Founded:  2015

Executive Chairman:  Howard Leonhardt

CEO:  Richard Koffler

Chief Medical Officer:  Dr. Leslie Miller

Vice President Business Development:  Jeff Donofrio

Vice President Electrical Stimulation R&D:  Dr. Jorge Genovese

Vice President COPD Research:  Dr. Syde Taheri

Lungs_diagram_detailed2016 Valuation:  $3 million 

Legal Structure:  Startup Licensable Technology Platform of Leonhardt Ventures (all lung regeneration related assets in step by step process of forming into a stand alone C corporation over time.

Business Plan:  2016 file patents, file grant applications, build and test prototypes, partner with universities working in this area of research especially in Los Angeles, San Francisco Bay Area, Minnesota, Atlanta, Boston, New York, North Carolina and Utah, complete pre-clinical studies.  2017 complete pilot OUS clinical trial in at least 20 patients, 2018 launch Phase II studies and find a strategic development partner or sell technology platform/startup.

Related Scientific Articles:

IGF-1

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Investigation of IGF-1 as a key driver of lung regeneration

bruker-microct.com/company/UM2016/oral02_Diana%20Engineer.pdf

Investigation of IGF1 as a key driver of lung regeneration. Diana E.6, Yasa J.1,2,3, Prele C.M.1,2, Laurent G.J.1,2, Lucas A.D.1,2, Liu L.4, Huang W.4, Lucas.

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Stem Cells in the Lung: Development, Repair and Regeneration

https://books.google.com/books?isbn=3319210823

Ivan Bertoncello – 2015 – ‎Science

Development, Repair and Regeneration Ivan Bertoncello. 35. … growth factor-1 (IGF1) and IGF1receptor (IGF-1R) expression in human lung in RDS and BPD.

Expression profile of IGF system during lung injury and … – NCBI

www.ncbi.nlm.nih.gov/…/16288470

National Center for Biotechnology Information

by TA Narasaraju – ‎2006 – ‎Cited by 34 – ‎Related articles

Expression profile of IGF system during lung injury and recovery in rats … lung injury, the role of these components in tissue repair is not well known. … The mRNA expression of IGF-I, IGF-II, and IGF1receptor (IGF-1R) increased during injury.

Regulation of cell proliferation by insulin-like growth factor 1 in … – NCBI

www.ncbi.nlm.nih.gov/…/11914039

National Center for Biotechnology Information

by A Chetty – ‎2002 – ‎Cited by 43 – ‎Related articles

Immunostaining of O2-exposed lung showed IGF1 was most abundant in airway … in the developmental and repair processes of hyperoxic neonatal lung injury.

Insulin-Like Growth Factor-1 Up-Regulates Surfactant Protein-B …

www.atsjournals.org/doi/pdf/…/ajrccm-conference.2014.189.1_MeetingAbstracts.A4993

by M Xiao

May 20, 2014 – C63 LUNG INJURY AND REPAIR: TWO TO TANGO … Additionally, insulin-like growth factor-1 (IGF1) is known to be crucial for multiple cells …

Role of IGF-1 pathway in lung fibroblast activation | Respiratory …

https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-14-102

by CF Hung – ‎2013 – ‎Cited by 8 – ‎Related articles

Oct 8, 2013 – IGF1 is elevated in pulmonary fibrosis and acute lung injury, where … changes that play an important role in lung injury and repair [13, 14].

SDF-1 

Role of the SDF-1/CXCR4 Axis in the Pathogenesis of Lung Injury and …

www.ncbi.nlm.nih.gov/…/PMC19942

National Center for Biotechnology Information

by J Xu – ‎2007 – ‎Cited by 130 – ‎Related articles

Apr 26, 2007 – Both SDF1 and lung lysates from bleomycin-treated mice induced … in an established animal model of lung injury, fibrosis, and repair. Studies 

Identification of vascular-derived signals for alveolar lung repair …

grantome.com/grant/NIH/R01-HL119872-03

Current therapeutic approaches for the repair of the injured lung tissue have … by deposition of VEGF-A and stromal derived factor-1 (SDF– 1, CXCl12) activate … or via infusion of normal engineered endothelial cells will restore lung repair.

Platelet-derived SDF-1 primes the pulmonary capillary vascular – NCBI

www.ncbi.nlm.nih.gov/…/25621952

National Center for Biotechnology Information

by S Rafii – ‎2015 – ‎Cited by 15 – ‎Related articles

Jan 26, 2015 – Platelet-derived SDF1 primes the pulmonary capillary vascular niche to drive lungalveolar regeneration. Rafii S(1), Cao Z(2), Lis R(3), …

eNOS

Lung Stem Cells in the Epithelium and Vasculature

https://books.google.com/books?isbn=3319162322

Amy Firth, ‎Jason X.-J. Yuan – 2015 – ‎Science

Vascular Repair and Regeneration by Endothelial Progenitor Cells Glenn … type 4 ECFCs Endothelial colony-forming cells eNOS Endothelial nitric oxide synthase … Hepatocyte growth factor IGF1 Insulin-like growth factor 1 IL10 Interleukin 10 …

Stem/progenitor cells in endogenous repairing responses: new …

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0804-1

by C Yang – ‎2016

Lung Proliferation Regeneration Repair Stem/progenitor cells Trauma and injury …. The main protective reasons referred to eNOS and eNOS-derived NO [35].

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(eNOS) expression and alveolar repair in elastase-induced rat

https://tsukuba.repo.nii.ac.jp/index.php?action

by H Ito – ‎Cited by 3 – ‎Related articles

Running head: Increased eNOS and Alveolar Repair. Hiromichi Ito. 1 … However, although the importance of eNOS expression in lung repair is recognized, the …

Follistatin

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The activin A antagonist follistatin inhibits cystic fibrosis-like lung …

www.nature.com › Journal home › Archive › Original Articles

Nature

by CL Hardy – ‎2015 – ‎Cited by 5 – ‎Related articles

Mar 10, 2015 – The activin A antagonist follistatin inhibits cystic fibrosis-like lung ….. A and its binding protein, follistatin, in inflammation and tissue repair.

Stem Cells

Stem cells might heal damaged lungs: Transplanted cells made their …

https://www.sciencedaily.com/releases/2015/07/150714100958.htm

Science Daily

Jul 14, 2015 – The study’s findings show how it might be possible to use embryonic stem cells to repairdamaged lung tissue. Share: FULL STORY …

Researchers discover new airway stem cell | UCLA

newsroom.ucla.edu/…/stemcell-researchers-disc…

University of California, Los Angeles

Jun 28, 2011 – Researchers at UCLA have identified a new stem cell that participates in the repair of the lungs‘ large airways, which play a vital role in ..

Investigators at The Saban Research Institute of Children’s Hospital …

www.chla.org/…/investigators-the-saban-research-insti

Children’s Hospital Los Angeles

LOS ANGELES (March 29, 2011) – Investigators at The Saban Research Institute of Children’s … Cellular polarity of lung epithelial cells, meaning that they have an … will help to harness theregenerative potential of lung stem cells, and to …

Developmental Biology and Regenerative Medicine Research Program

www.chla.org/developmental-biology-and-regenerati

Children’s Hospital Los Angeles

… of human adult and child health, where organ regenerationstem cell based therapy or … AtChildren’s Hospital Los Angeles, therapeutic targets for eventual … the bedside include lunghypoplasia or injury caused by prematurity, cleft palate, …

Lung Cells Can Regenerate Themselves, Finding Could Bring New …

www.techtimes.com/…/lung-cells-can-regenerate-themselves-finding-could-bring-new…

Apr 13, 2015 – Cells in lung tissue show a surprising ability to regenerate and differentiate to repairlung damage, study finds. … Lung tissue is better at regenerating itself after injury than previously thought, a discovery that could improve the treatment of some lung and breathing disorders ..

Limber Lungs: One Type of Airway Cell Can Regenerate Another …

www.uphs.upenn.edu/news/news_releases/2015/…/epstein/

University of Pennsylvania

Apr 13, 2015 – Findings from animal study have implications for disorders such as chronic obstructive pulmonary disease. PHILADELPHIA – A new collaborative study describes a way that lung tissue canregenerate after injury. The team found that lung tissue has more dexterity in repairing tissue than once thought.

Stem cells might heal damaged lungs: Transplanted cells made their …

https://www.sciencedaily.com/releases/2015/07/150714100958.htm

Science Daily

Jul 14, 2015 – Collectively, such diseases of the airways as emphysema, bronchitis, asthma and cystic fibrosis are the second leading cause of death …

Research indicates that stem cells could be used to heal damaged lungs

www.gizmag.com/stemcells-treat-damaged-lungs/38447/

Gizmag

Jul 20, 2015 – Respiratory diseases are extremely prevalent, with more than 35 million sufferers in the US alone. Now, a team from the Weizmann Institute of …

Current Status of Stem Cells and Regenerative Medicine in Lung …

www.ncbi.nlm.nih.gov/…/PMC42085

National Center for Biotechnology Information

by DJ Weiss – ‎2014 – ‎Cited by 49 – ‎Related articles

Keywords: Lunglung regenerationlung diseases, endogenous progenitor cell, …. the administered cells, paracrine stimulation of endogenous vascular progenitor …. vivo engineering of functional lungtissues that can be surgically implanted.

VEGF

Search Results

Lung regeneration closer to reality with new discovery by Weill Cornell …

www.eurekalert.org/pub_releases/2011-10/nyph-lrc102811.php

Oct 28, 2011 – Study’s authors show blood vessels support lung regeneration and their … that respond to vascular endothelial growth factor (VEGF) and basic …

A Breath of Fresh Air in Lung Regeneration

www.ncbi.nlm.nih.gov/…/PMC32894

National Center for Biotechnology Information

by S Beronja – ‎2011 – ‎Cited by 3 – ‎Related articles

Oct 28, 2011 – Enhancing the ability of the lungs to regenerate following injury could … the authors identified VEGF and FGF signaling-dependent expression …

Vascular endothelial growth factor (VEGF) in acute lung injury (ALI …

www.ncbi.nlm.nih.gov/…/PMC18286

National Center for Biotechnology Information

by ARL Medford – ‎2006 – ‎Cited by 78 – ‎Related articles

Vascular endothelial cell growth factor (VEGF) was identified by its … that VEGF protects the alveolar epithelium with a role in repair following lung injury, but …

Hypoxia-inducible factors promote alveolar development and … – NCBI

www.ncbi.nlm.nih.gov/…/23962064

National Center for Biotechnology Information

by A Vadivel – ‎2014 – ‎Cited by 18 – ‎Related articles

Recent evidence suggests that lung angiogenesis promotes lung development and repair. Vascular endothelial growth factor (VEGF) preserves lung …

HGF- Hepatocyte Growth Factor

Hepatocyte growth factor may act as a pulmotrophic factor on lung …

www.ncbi.nlm.nih.gov/…/8407957

National Center for Biotechnology Information

by K Yanagita – ‎1993 – ‎Cited by 243 – ‎Related articles

J Biol Chem. 1993 Oct 5;268(28):21212-7. Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury. Yanagita K(1) …

Emerging Multipotent Aspects of Hepatocyte Growth Factor

jb.oxfordjournals.org/content/119/4/591.full.pdf

Journal of Biochemistry

by K Matsumoto – ‎1996 – ‎Cited by 646 – ‎Related articles

established that hepatocyte growth factor (HGF), a ligand for the c-met protooncogene … HGF elicits a potent organotrophic function which supports regeneration of organs includ- ….. c-Met/HGF receptor mRNA in developing lung of day 13 of.

Hepatocyte growth factor in lung repair and pulmonary fibrosis

https://www.researchgate.net/…/49658698_Hepatocyte_growth_factor_in_l ResearchGate

Hepatocyte growth factor in lung repair and pulmonary fibrosis on ResearchGate, the professional network for scientists.

EGF – Epidermal Growth Factor

Role of epidermal growth factor receptor in DNA damage repair

link.springer.com/content/…/s11434-011-4650-5.pd

Springer Science+Business Media

by JC Lu – ‎2011 – ‎Cited by 3 – ‎Related articles

Role of epidermal growth factor receptor in DNA damage repair. LU JingChen1,2 …. cells [13], but not in nonsmall cell lung carcinoma (NSCLC) cell lines A549 …

Role of epidermal growth factor receptor activation in regulating mucin …

respiratory-research.biomedcentral.com/articles/10.1186/rr43

by JA Nadel – ‎2001 – ‎Cited by 112 – ‎Related articles

These cells are also believed to be the cells of origin of non-small-cell lung cancer, but this …Epidermal growth factor expression and activation causes goblet-cell …. damaged bronchial epithelialrepair is accelerated by EGFR activation [30].

Roles of epidermal growth factor receptor activation in … – NCBI

www.ncbi.nlm.nih.gov/…/PMC17468

National Center for Biotechnology Information

by P Burgel – ‎2004 – ‎Cited by 208 – ‎Related articles

Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin …. Growth factors accelerate epithelial repair in sheep trachea. Lung. 1993 …

Tropoelastin

The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber …

www.ncbi.nlm.nih.gov/…/PMC26587

National Center for Biotechnology Information

by A Shifren – ‎2006 – ‎Cited by 108 – ‎Related articles

Exacerbating the disease process is the inability of lung cells to repair damaged … Keywords: elastin,elastin mutations, emphysema, extracellular matrix, repair.

Regulation of lung fibroblast tropoelastin expression by alveolar …

www.ncbi.nlm.nih.gov/pubmed/9458800 National Center for Biotechnology Information

by TJ Mariani – ‎1998 – ‎Cited by 16 – ‎Related articles

Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells. … interactions are of critical importance during tissue morphogenesis and repair.

Electrical Stimulation

Role of electrical stimulation for rehabilitation and regeneration after …

www.ncbi.nlm.nih.gov/…/PMC25274

National Center for Biotechnology Information

by S Hamid – ‎2008 – ‎Cited by 118 – ‎Related articles

Aug 2, 2008 – Electrical stimulation in the form of functional electrical stimulation (FES) ….. as well as normal lung function and normal chest wall compliance.

Microcurrent Therapy a Holistic Option for Lung Health – HolisticHorse …

holistichorse.com/equine…/microcurrent-therapy-a-holistic-option-for-lung-health/

Microcurrent therapy is a holistic option for improving equine lung health , and … EIPH to race, however, it does not repair the damage done to the horse’s lungs.

The clinical use of regenerative therapy in COPD

www.ncbi.nlm.nih.gov/…/PMC42717

National Center for Biotechnology Information

by R Lipsi – ‎2014 – ‎Cited by 1 – ‎Related articles

Dec 12, 2014 – Regenerative or stem cell therapy is an emerging field of treatment based on stimulation … Current evidence suggests that in the lung, these cells may …. subtypes, depending on their origin and the resident microenvironment.

Related Patents and Research

Patent US5788668 – Vibrational enhancement of intravenous … – Google

www.google.ch/patents/US5788668

Google

The presence of the vibration increases the efficiency of intravenous gas exchanging … Erfinder,Howard J. Leonhardt …. One type of catheter allows vital gas exchange to occur within the body if thelungs can not function properly. …. is to provide a method which will prevent clotting of long-termintravascular devices.

Patent WO2001042425A2 – Lung stem cells and lung regeneration …

https://www.google.com/patents/WO2001042425A2?cl=en14 Google

… progenitor or stem cells capable of regenerating lung alveolar surface, and … stem cells to thelung in an amount sufficient to stimulate the growth of lung … Barbara Driscoll, Los Angeles Childrens Hospital, Margaret Schwarz, David Warburton … Children’s Medical Center Corporation, Acceleration of tissue growth using …

Lung Stem Cells for Therapeutic Lung Regeneration – 14160 – North …

licensing.research.ncsu.edu/…/14160_lungstemcells-for-therapeutic-lungregenerati

A U.S. provisional patent application has been filed. Abstract. Pulmonary … Stem cell therapy is a promising approach to lung regeneration medicine. Current …

Lung Regeneration | The Ott Laboratory for Organ Engineering and …

ottlab.mgh.harvard.edu/?page_id=55

Harvard University

The lung project focuses on the goal of deriving a functioning, transplantable human lung by combining native extracellular matrix scaffolds and novel …

Researchers find bioreactor supports whole lung regeneration – UPI.com

www.upi.com/Health_News/2016/05/04/lungregeneration/7211462377502/

May 4, 2016 – Researchers at Yale University devised a mechanical system that can support the growth of whole lungs from patient cells to use in transplants.

Search Results

[PDF]

Call Longfonds Regeneration of the lung – Longfonds Research

research.longfonds.nl/…/DEF%20-%20%20Longherstel%20draft%20call%20for%20

Research in regeneration of lung tissue has rapidly developed in the past years, and the … tissue printing and advanced models to study elements of lung (patho)physiology point to the technological potential in The Netherlands and beyond.

Lung Regeneration – Center for Regenerative Medicine – Mayo Clinic …

www.mayo.edu/research/centers-programs/center-regenerative…/lungregeneration

Regenerative medicine has the potential to provide innovative new therapies for people with lungdiseases, including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension and bronchiolitis obliterans. … Research into lung …

Missing: netherlands

Regeneration of the lung: Lung stem cells and the development of …

www.ncbi.nlm.nih.gov/…/PMC4842297/ National Center for Biotechnology Information

by KAA Schilders – ‎2016

Apr 23, 2016 – Keywords: Lung, Stem cells, Regeneration, Tissue engineering, Lung mimics …. A newstudy shows Trp73 as a regulator of ciliated cell differentiation, ….. by the Lung FoundationNetherlands, project 6.1.14.010, the Sophia …

Regenerative Medicine Study Underscores Lung Regeneration Capacity

cysticfibrosisnewstoday.com/…/regenerative-medicine-study-underscores-lungregene

Apr 28, 2015 – In diseases like cystic fibrosis, the lungs undergo constant healing and remodeling due to chronic infections. To better understand the repair …

Biomimetic platforms for human stem cell research

www.ncbi.nlm.nih.gov/…/PMC30488

National Center for Biotechnology Information

by G Vunjak-Novakovic – ‎2011 – ‎Cited by 88 – ‎Related articles

Mar 4, 2011 – The regeneration of worn and diseased tissues using some form of ….. Subjecting stem cells to electrical stimulation and mechanical … Remarkably, these engineered lungs functioned in vivo, and persisted for several hours.