REGENALUNG
RegenaLung is a startup within the Leonhardt Ventures Cal-X Stars Business Accelerator and Leonhardt’s Launchpads Utah focused on lung regeneration.
The company utilizes bioelectric stimulation to control release of specific proteins on demand for specific regenerative purposes in sequence:
1. SDF-1 (stem cell homing factor – recruits a persons own stem cells to stimulated tissues).
2. VEGF (for new blood vessel growth).
3 IGF-1 (for DNA repair at the nucleus level).
4. Follistatin (for muscle and tissue regeneration).
5. RANKL (for demineralization and tissue loosening when needed).
6. Hepatocyte Growth Factor (tissue regeneration)
7. eNOS (for dilating blood vessels for increasing flow).
8. Tropoelastin (increases elasticity of any tissues such as skin, arteries, aorta, heart and promotes healing of wounds).
9. Activin A + B (regeneration)
10. EGF.
In extreme cases we combine our regeneration micro stimulator with our patented implantable, programmable, re-fillable stem cell/growth factor micro pump – www.fluidsynchrony.com
In cases of lung cancer we have special signals to stop tumor cell division and blood supply followed by the above regeneration protocol – http://mysocialgoodnews.com/leonhardt-ventures-cerebracell-file-patent-application-bioelectric-signals-halt-tumor-growth-regenerate-organs/
We also have a subsidiary Regenalung COPD to address COPD.
Corporate Information:
Founded: 2015
Executive Chairman: Howard Leonhardt
CEO: Richard Koffler
Chief Medical Officer: Dr. Leslie Miller
Vice President Business Development: Jeff Donofrio
Vice President Electrical Stimulation R&D: Dr. Jorge Genovese
Vice President COPD Research: Dr. Syde Taheri
Related Scientific Articles
Evaluation of the Role of Hedgehog Interacting Protein (HHIP) and the Sonic Hedgehog Pathway to Enhance Respiratory Repair and Function in Chronic Obstructive Pulmonary Disease (COPD) – Click Here
Predifferentiated amniotic fluid mesenchymal stem cells enhance lung alveolar epithelium regeneration and reverse elastase-induced pulmonary emphysema – Click Here
Pulmonary alveolar regeneration in adult COVID-19 patients – Click Here
How airway cells work together in regeneration and aging – Click Here
The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance – Click here
Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction – Click here
How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem Cells – Click here
Neuromuscular electrical stimulation improves clinical and physiological function in COPD patients
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197006
IGF-1
[PDF]
Investigation of IGF-1 as a key driver of lung regeneration
bruker-microct.com/company/UM2016/oral02_Diana%20Engineer.pdf
Investigation of IGF–1 as a key driver of lung regeneration. Diana E.6, Yasa J.1,2,3, Prele C.M.1,2, Laurent G.J.1,2, Lucas A.D.1,2, Liu L.4, Huang W.4, Lucas.
You’ve visited this page 5 times. Last visit: 6/20/16
Stem Cells in the Lung: Development, Repair and Regeneration
https://books.google.com/books?isbn=3319210823
Ivan Bertoncello – 2015 – Science
Development, Repair and Regeneration Ivan Bertoncello. 35. … growth factor-1 (IGF–1) and IGF–1receptor (IGF-1R) expression in human lung in RDS and BPD.
Expression profile of IGF system during lung injury and … – NCBI
www.ncbi.nlm.nih.gov/…/16288470
National Center for Biotechnology Information
by TA Narasaraju – 2006 – Cited by 34 – Related articles
Expression profile of IGF system during lung injury and recovery in rats … lung injury, the role of these components in tissue repair is not well known. … The mRNA expression of IGF-I, IGF-II, and IGF–1receptor (IGF-1R) increased during injury.
Regulation of cell proliferation by insulin-like growth factor 1 in … – NCBI
www.ncbi.nlm.nih.gov/…/11914039
National Center for Biotechnology Information
by A Chetty – 2002 – Cited by 43 – Related articles
Immunostaining of O2-exposed lung showed IGF–1 was most abundant in airway … in the developmental and repair processes of hyperoxic neonatal lung injury.
Insulin-Like Growth Factor-1 Up-Regulates Surfactant Protein-B …
www.atsjournals.org/doi/pdf/…/ajrccm-conference.2014.189.1_MeetingAbstracts.A4993
by M Xiao
May 20, 2014 – C63 LUNG INJURY AND REPAIR: TWO TO TANGO … Additionally, insulin-like growth factor-1 (IGF–1) is known to be crucial for multiple cells …
Role of IGF-1 pathway in lung fibroblast activation | Respiratory …
https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-14-102
by CF Hung – 2013 – Cited by 8 – Related articles
Oct 8, 2013 – IGF–1 is elevated in pulmonary fibrosis and acute lung injury, where … changes that play an important role in lung injury and repair [13, 14].
SDF-1
Role of the SDF-1/CXCR4 Axis in the Pathogenesis of Lung Injury and …
www.ncbi.nlm.nih.gov/…/PMC19942…
National Center for Biotechnology Information
by J Xu – 2007 – Cited by 130 – Related articles
Apr 26, 2007 – Both SDF–1 and lung lysates from bleomycin-treated mice induced … in an established animal model of lung injury, fibrosis, and repair. Studies
Identification of vascular-derived signals for alveolar lung repair …
grantome.com/grant/NIH/R01-HL119872-03
Current therapeutic approaches for the repair of the injured lung tissue have … by deposition of VEGF-A and stromal derived factor-1 (SDF– 1, CXCl12) activate … or via infusion of normal engineered endothelial cells will restore lung repair.
Platelet-derived SDF-1 primes the pulmonary capillary vascular – NCBI
www.ncbi.nlm.nih.gov/…/25621952
National Center for Biotechnology Information
by S Rafii – 2015 – Cited by 15 – Related articles
Jan 26, 2015 – Platelet-derived SDF–1 primes the pulmonary capillary vascular niche to drive lungalveolar regeneration. Rafii S(1), Cao Z(2), Lis R(3), …
eNOS
Lung Stem Cells in the Epithelium and Vasculature
https://books.google.com/books?isbn=3319162322
Amy Firth, Jason X.-J. Yuan – 2015 – Science
Vascular Repair and Regeneration by Endothelial Progenitor Cells Glenn … type 4 ECFCs Endothelial colony-forming cells eNOS Endothelial nitric oxide synthase … Hepatocyte growth factor IGF1 Insulin-like growth factor 1 IL10 Interleukin 10 …
Stem/progenitor cells in endogenous repairing responses: new …
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0804-1
by C Yang – 2016
Lung Proliferation Regeneration Repair Stem/progenitor cells Trauma and injury …. The main protective reasons referred to eNOS and eNOS-derived NO [35].
[PDF]
(eNOS) expression and alveolar repair in elastase-induced rat
https://tsukuba.repo.nii.ac.jp/index.php?action…
by H Ito – Cited by 3 – Related articles
Running head: Increased eNOS and Alveolar Repair. Hiromichi Ito. 1 … However, although the importance of eNOS expression in lung repair is recognized, the …
Follistatin
Search Results
The activin A antagonist follistatin inhibits cystic fibrosis-like lung …
www.nature.com › Journal home › Archive › Original Articles
Nature
by CL Hardy – 2015 – Cited by 5 – Related articles
Mar 10, 2015 – The activin A antagonist follistatin inhibits cystic fibrosis-like lung ….. A and its binding protein, follistatin, in inflammation and tissue repair.
Stem Cells
Stem cells might heal damaged lungs: Transplanted cells made their …
https://www.sciencedaily.com/releases/2015/07/150714100958.htm
Science Daily
Jul 14, 2015 – The study’s findings show how it might be possible to use embryonic stem cells to repairdamaged lung tissue. Share: FULL STORY …
Researchers discover new airway stem cell | UCLA
newsroom.ucla.edu/…/stem–cell-researchers-disc…
University of California, Los Angeles
Jun 28, 2011 – Researchers at UCLA have identified a new stem cell that participates in the repair of the lungs‘ large airways, which play a vital role in ..
Investigators at The Saban Research Institute of Children’s Hospital …
www.chla.org/…/investigators-the-saban-research-insti…
Children’s Hospital Los Angeles
LOS ANGELES (March 29, 2011) – Investigators at The Saban Research Institute of Children’s … Cellular polarity of lung epithelial cells, meaning that they have an … will help to harness theregenerative potential of lung stem cells, and to …
Developmental Biology and Regenerative Medicine Research Program
www.chla.org/developmental-biology-and-regenerati…
Children’s Hospital Los Angeles
… of human adult and child health, where organ regeneration, stem cell based therapy or … AtChildren’s Hospital Los Angeles, therapeutic targets for eventual … the bedside include lunghypoplasia or injury caused by prematurity, cleft palate, …
Lung Cells Can Regenerate Themselves, Finding Could Bring New …
www.techtimes.com/…/lung-cells-can-regenerate-themselves-finding-could-bring-new…
Apr 13, 2015 – Cells in lung tissue show a surprising ability to regenerate and differentiate to repairlung damage, study finds. … Lung tissue is better at regenerating itself after injury than previously thought, a discovery that could improve the treatment of some lung and breathing disorders ..
Limber Lungs: One Type of Airway Cell Can Regenerate Another …
www.uphs.upenn.edu/news/news_releases/2015/…/epstein/
University of Pennsylvania
Apr 13, 2015 – Findings from animal study have implications for disorders such as chronic obstructive pulmonary disease. PHILADELPHIA – A new collaborative study describes a way that lung tissue canregenerate after injury. The team found that lung tissue has more dexterity in repairing tissue than once thought.
Stem cells might heal damaged lungs: Transplanted cells made their …
https://www.sciencedaily.com/releases/2015/07/150714100958.htm
Science Daily
Jul 14, 2015 – Collectively, such diseases of the airways as emphysema, bronchitis, asthma and cystic fibrosis are the second leading cause of death …
Research indicates that stem cells could be used to heal damaged lungs
www.gizmag.com/stem–cells-treat-damaged-lungs/38447/
Gizmag
Jul 20, 2015 – Respiratory diseases are extremely prevalent, with more than 35 million sufferers in the US alone. Now, a team from the Weizmann Institute of …
Current Status of Stem Cells and Regenerative Medicine in Lung …
www.ncbi.nlm.nih.gov/…/PMC42085…
National Center for Biotechnology Information
by DJ Weiss – 2014 – Cited by 49 – Related articles
Keywords: Lung, lung regeneration, lung diseases, endogenous progenitor cell, …. the administered cells, paracrine stimulation of endogenous vascular progenitor …. vivo engineering of functional lungtissues that can be surgically implanted.
VEGF
Search Results
Lung regeneration closer to reality with new discovery by Weill Cornell …
www.eurekalert.org/pub_releases/2011-10/nyph-lrc102811.php
Oct 28, 2011 – Study’s authors show blood vessels support lung regeneration and their … that respond to vascular endothelial growth factor (VEGF) and basic …
A Breath of Fresh Air in Lung Regeneration
www.ncbi.nlm.nih.gov/…/PMC32894…
National Center for Biotechnology Information
by S Beronja – 2011 – Cited by 3 – Related articles
Oct 28, 2011 – Enhancing the ability of the lungs to regenerate following injury could … the authors identified VEGF and FGF signaling-dependent expression …
Vascular endothelial growth factor (VEGF) in acute lung injury (ALI …
www.ncbi.nlm.nih.gov/…/PMC18286…
National Center for Biotechnology Information
by ARL Medford – 2006 – Cited by 78 – Related articles
Vascular endothelial cell growth factor (VEGF) was identified by its … that VEGF protects the alveolar epithelium with a role in repair following lung injury, but …
Hypoxia-inducible factors promote alveolar development and … – NCBI
www.ncbi.nlm.nih.gov/…/23962064
National Center for Biotechnology Information
by A Vadivel – 2014 – Cited by 18 – Related articles
Recent evidence suggests that lung angiogenesis promotes lung development and repair. Vascular endothelial growth factor (VEGF) preserves lung …
HGF- Hepatocyte Growth Factor
Hepatocyte growth factor may act as a pulmotrophic factor on lung …
www.ncbi.nlm.nih.gov/…/8407957
National Center for Biotechnology Information
by K Yanagita – 1993 – Cited by 243 – Related articles
J Biol Chem. 1993 Oct 5;268(28):21212-7. Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury. Yanagita K(1) …
Emerging Multipotent Aspects of Hepatocyte Growth Factor
jb.oxfordjournals.org/content/119/4/591.full.pdf
Journal of Biochemistry
by K Matsumoto – 1996 – Cited by 646 – Related articles
established that hepatocyte growth factor (HGF), a ligand for the c-met protooncogene … HGF elicits a potent organotrophic function which supports regeneration of organs includ- ….. c-Met/HGF receptor mRNA in developing lung of day 13 of.
Hepatocyte growth factor in lung repair and pulmonary fibrosis
https://www.researchgate.net/…/49658698_Hepatocyte_growth_factor_in_l… ResearchGate
Hepatocyte growth factor in lung repair and pulmonary fibrosis on ResearchGate, the professional network for scientists.
EGF – Epidermal Growth Factor
Role of epidermal growth factor receptor in DNA damage repair
link.springer.com/content/…/s11434-011-4650-5.pd…
Springer Science+Business Media
by JC Lu – 2011 – Cited by 3 – Related articles
Role of epidermal growth factor receptor in DNA damage repair. LU JingChen1,2 …. cells [13], but not in nonsmall cell lung carcinoma (NSCLC) cell lines A549 …
Role of epidermal growth factor receptor activation in regulating mucin …
respiratory-research.biomedcentral.com/articles/10.1186/rr43
by JA Nadel – 2001 – Cited by 112 – Related articles
These cells are also believed to be the cells of origin of non-small-cell lung cancer, but this …Epidermal growth factor expression and activation causes goblet-cell …. damaged bronchial epithelialrepair is accelerated by EGFR activation [30].
Roles of epidermal growth factor receptor activation in … – NCBI
www.ncbi.nlm.nih.gov/…/PMC17468…
National Center for Biotechnology Information
by P Burgel – 2004 – Cited by 208 – Related articles
Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin …. Growth factors accelerate epithelial repair in sheep trachea. Lung. 1993 …
Tropoelastin
The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber …
www.ncbi.nlm.nih.gov/…/PMC26587…
National Center for Biotechnology Information
by A Shifren – 2006 – Cited by 108 – Related articles
Exacerbating the disease process is the inability of lung cells to repair damaged … Keywords: elastin,elastin mutations, emphysema, extracellular matrix, repair.
Regulation of lung fibroblast tropoelastin expression by alveolar …
www.ncbi.nlm.nih.gov/pubmed/9458800 National Center for Biotechnology Information
by TJ Mariani – 1998 – Cited by 16 – Related articles
Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells. … interactions are of critical importance during tissue morphogenesis and repair.
Electrical Stimulation
Role of electrical stimulation for rehabilitation and regeneration after …
www.ncbi.nlm.nih.gov/…/PMC25274…
National Center for Biotechnology Information
by S Hamid – 2008 – Cited by 118 – Related articles
Aug 2, 2008 – Electrical stimulation in the form of functional electrical stimulation (FES) ….. as well as normal lung function and normal chest wall compliance.
Microcurrent Therapy a Holistic Option for Lung Health – HolisticHorse …
holistichorse.com/equine…/microcurrent-therapy-a-holistic-option-for-lung-health/
Microcurrent therapy is a holistic option for improving equine lung health , and … EIPH to race, however, it does not repair the damage done to the horse’s lungs.
The clinical use of regenerative therapy in COPD
www.ncbi.nlm.nih.gov/…/PMC42717…
National Center for Biotechnology Information
by R Lipsi – 2014 – Cited by 1 – Related articles
Dec 12, 2014 – Regenerative or stem cell therapy is an emerging field of treatment based on stimulation … Current evidence suggests that in the lung, these cells may …. subtypes, depending on their origin and the resident microenvironment.
Related Patents and Research
Patent US5788668 – Vibrational enhancement of intravenous … – Google
www.google.ch/patents/US5788668
The presence of the vibration increases the efficiency of intravenous gas exchanging … Erfinder,Howard J. Leonhardt …. One type of catheter allows vital gas exchange to occur within the body if thelungs can not function properly. …. is to provide a method which will prevent clotting of long-termintravascular devices.
Patent WO2001042425A2 – Lung stem cells and lung regeneration …
https://www.google.com/patents/WO2001042425A2?cl=en14 Google
… progenitor or stem cells capable of regenerating lung alveolar surface, and … stem cells to thelung in an amount sufficient to stimulate the growth of lung … Barbara Driscoll, Los Angeles Childrens Hospital, Margaret Schwarz, David Warburton … Children’s Medical Center Corporation, Acceleration of tissue growth using …
Lung Stem Cells for Therapeutic Lung Regeneration – 14160 – North …
licensing.research.ncsu.edu/…/14160_lung–stem–cells-for-therapeutic-lung–regenerati…
A U.S. provisional patent application has been filed. Abstract. Pulmonary … Stem cell therapy is a promising approach to lung regeneration medicine. Current …
Lung Regeneration | The Ott Laboratory for Organ Engineering and …
ottlab.mgh.harvard.edu/?page_id=55
Harvard University
The lung project focuses on the goal of deriving a functioning, transplantable human lung by combining native extracellular matrix scaffolds and novel …
Researchers find bioreactor supports whole lung regeneration – UPI.com
www.upi.com/Health_News/2016/05/04/…lung–regeneration/7211462377502/
May 4, 2016 – Researchers at Yale University devised a mechanical system that can support the growth of whole lungs from patient cells to use in transplants.
Search Results
[PDF]
Call Longfonds Regeneration of the lung – Longfonds Research
research.longfonds.nl/…/DEF%20-%20%20Longherstel%20draft%20call%20for%20…
Research in regeneration of lung tissue has rapidly developed in the past years, and the … tissue printing and advanced models to study elements of lung (patho)physiology point to the technological potential in The Netherlands and beyond.
Lung Regeneration – Center for Regenerative Medicine – Mayo Clinic …
www.mayo.edu/research/centers-programs/center-regenerative…/lung–regeneration
Regenerative medicine has the potential to provide innovative new therapies for people with lungdiseases, including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension and bronchiolitis obliterans. … Research into lung …
Missing: netherlands
Regeneration of the lung: Lung stem cells and the development of …
www.ncbi.nlm.nih.gov/…/PMC4842297/ National Center for Biotechnology Information
by KAA Schilders – 2016
Apr 23, 2016 – Keywords: Lung, Stem cells, Regeneration, Tissue engineering, Lung mimics …. A newstudy shows Trp73 as a regulator of ciliated cell differentiation, ….. by the Lung FoundationNetherlands, project 6.1.14.010, the Sophia …
Regenerative Medicine Study Underscores Lung Regeneration Capacity
cysticfibrosisnewstoday.com/…/regenerative-medicine-study-underscores-lung–regene…
Apr 28, 2015 – In diseases like cystic fibrosis, the lungs undergo constant healing and remodeling due to chronic infections. To better understand the repair …
Biomimetic platforms for human stem cell research
www.ncbi.nlm.nih.gov/…/PMC30488…
National Center for Biotechnology Information
by G Vunjak-Novakovic – 2011 – Cited by 88 – Related articles
Mar 4, 2011 – The regeneration of worn and diseased tissues using some form of ….. Subjecting stem cells to electrical stimulation and mechanical … Remarkably, these engineered lungs functioned in vivo, and persisted for several hours.
