Endocell

bioEndoCell is a Leonhardt Ventures startup incubating in the Cal-X Stars Business Accelerator, Inc. in Santa Monica, CA with support R&D lab support assistance from Leonhardt’s Launchpads NorCal at the University of Northern California Science and Technology Center (UNC STIC) and Leonhardt’s Launchpads Utah just off campus of University of Utah in Salt Lake City, UT.   EndoCell is focused on artery regeneration.

The EndoCell Artery Regeneration procedure includes these steps:

1.  Arthrectomy of narrowed plaque ridden artery.

2.  Harvesting of endothelial progenitor cells from the patient’s own fat tissue.

3.  Injection of endothelial progenitor cells into post athrectomy adventia of artery with micro needle catheter – http://www.mercatormed.com/bullfrog-micro-infusion-device/

4.  Micro bioelectric energy delivery to post treatment artery inner lining with bioelectic energy delivery endovascular catheter.  Bioelectric signals for controlled release of SDF-1 (stem cell homing), IGF-1, HGF, EGF, Follistatin, eNOS, VEGF and Tropoelastin. 

5.  Timed infusion of endothelial progenitor cells and anti-inflammatory agents.

6.  Timed infusion of EC-8 proprietary artery regeneration cocktail via micro pump.

7.  External wireless microcurrent energy treatments. 

Collaborating Researchers include:

Dr. Warren Sherman – Chief Medical Advisor

Dr. Lelsie Miller – Chief Medical Officer – Morton Plant Hospital, Florida

Dr. Stuart Williams – VP of Research and Development – U of Louisville

Dr. Dayu Teng – Researcher UC San Diego 

Dr. Jorge Genovese – Researcher Argentina

Dr. Antonio Colombo – Researcher Italy

Dr. Doris Taylor – Researcher – Texas Heart Institute

Dr. Tuan Hoang – Micro Pump Researcher – USC+Fluid Synchrony 

Related Articles:

The Intima

circres.ahajournals.org/content/77/3/445.full

Circulation Research

by SM Schwartz – ‎1995 – ‎Cited by 1026 – ‎Related articles

Top right, Advanced atherosclerosis of the left circumflex coronary artery. … Directional coronaryatherectomy specimen from a restenotic lesion shows stellate-shaped …. Regeneration of the endothelium inhibits proliferation of the underlying neointimal cells. …… Similar results have been found in the swine by Post et al.

Insulin-Like Growth Factor-1 as a Vascular Protective Factor – Circulation

circ.ahajournals.org/content/110/15/2260.full

Circulation

by E Conti – ‎2004 – ‎Cited by 186 – ‎Related articles

Thus, IGF1 has been considered a promoter of arterial obstructive lesions; ….. may favor endothelial and parenchimal regeneration at sites of tissue damage.

Cardioprotection of Insulin-Like Growth Factor-1 During Reperfusion …

circinterventions.ahajournals.org/content/4/4/311.full

by W Dai – ‎2011 – ‎Cited by 3 – ‎Related articles

This regenerative capability of IGF1 may have helped to explain the … artery and injected fibroblast growth factor-2, IGF1, hepatocyte growth factor, and stromal …

Full Text – Circulation: Cardiovascular Interventions

circinterventions.ahajournals.org/content/4/4/311.full

by W Dai – ‎2011 – ‎Cited by 3 – ‎Related articles

IGF1 enhanced cardiac repair after infarction through potentiating the activation … ligated the leftcoronary artery and injected fibroblast growth factor-2, IGF1, …

Cardioprotection of Insulin-Like Growth Factor-1 During Reperfusion …

circinterventions.ahajournals.org/content/4/4/311.full.pdf

by W Dai – ‎2011 – ‎Cited by 3 – ‎Related articles

ing coronary artery for 90 minutes followed by 2 hours of reperfusion. At the end of …. artery in rats. 1 mo. IGF1 enhanced cardiac repair after infarction through.

Impact of insulin like growth factor-1 in development of coronary artery …

www.ncbi.nlm.nih.gov/…/PMC4333962/ National Center for Biotechnology Information

by IF Akturk – ‎2014 – ‎Related articles

Severe coronary wall inflammation may play a role in CAE pathogenesis [10,11]. Insulin-like growth factor-1 (IGF1) has anti-inflammatory and pro-repairing …

Hepatocyte growth factor in patients with coronary artery disease and …

www.ncbi.nlm.nih.gov/…/PMC3862344/ National Center for Biotechnology Information

by J Lönn – ‎2012 – ‎Cited by 9 – ‎Related articles

Dec 30, 2011 – Hepatocyte growth factor (HGF) is an angiogenic, cardioprotective factor important for tissue and vascular repair. High levels of HGF are …

Hepatocyte growth factor mobilizes non-bone marrow-derived …

eurheartj.oxfordjournals.org/content/32/5/627

European Heart Journal

by M Iwasaki – ‎2011 – ‎Cited by 8 – ‎Related articles

Dec 29, 2010 – Conclusions Hepatocyte growth factor induces mobilization of ….. aortic or mitral valvereplacement (n = 6), and off-pump coronary artery …

Endothelial Progenitor Cells and Vascular Repair

www.ncbi.nlm.nih.gov/…/PMC40900…

National Center for Biotechnology Information

by M Zhang – ‎2014 – ‎Cited by 20 – ‎Related articles

Purpose of review. Identify recent advances in the field of vascular repair by regenerative endothelial cells (ECs) and endothelial progenitor cells (EPCs).

Study finds coronary arteries hold heart-regenerating cells | Research …

news.vanderbilt.edu/…/coronaryarteries-heart-regenerating-cell…

Vanderbilt University

Aug 20, 2014 – Endothelial cells residing in the coronary arteries can function as cardiac stem cells to produce new heart muscle tissue, Vanderbilt University …

Surprise Origin for Coronary Arteries Could Speed Advances in …

www.einstein.yu.edu › Newsroom › News Releases

Albert Einstein College of Medicine

Nov 21, 2012 – Researchers at Albert Einstein College of Medicine find the surprise origin for coronary arteries that could speed advances in regenerative …

Engineering of arteries in vitro – NCBI – National Institutes of Health

www.ncbi.nlm.nih.gov/…/PMC40243…

National Center for Biotechnology Information

by AH Huang – ‎2014 – ‎Cited by 17 – ‎Related articles

Jan 8, 2014 – Over 570,000 coronary artery bypasses are performed each year [1]. As a result …. Bell and Weinberg pioneered the in vitro regeneration of blood vessels by ….. Type I collagen andtropoelastin mRNA levels were significantly …

Origin of Extracellular Matrix Synthesis During Coronary Repair

circ.ahajournals.org/content/95/4/997.long Circulation

by Y Shi – ‎1997 – ‎Cited by 123 – ‎Related articles

Regenerating endothelial cells are positive for BrdU. … Tropoelastin transcripts were not detectable in normal coronary arteries by in situ hybridization (n=6).

Tropoelastin Gene Expression in Individual Vascular Smooth Muscle …

circres.ahajournals.org/content/78/3/388.full

Circulation Research

by JK Belknap – ‎1996 – ‎Cited by 38 – ‎Related articles

Tropoelastin Gene Expression in Individual Vascular Smooth Muscle Cells ….. Relation between activated smooth-muscle cells in coronaryartery lesions and …

The impact of patient co-morbidities on the regenerative capacity of …

www.ncbi.nlm.nih.gov/…/PMC4880978/ National Center for Biotechnology Information

by AE Mayfield – ‎2016

May 26, 2016 – Therefore, we investigated the influence of cardiac risk factors on the … growth factor-1 (IGF-1) and 50 ng/mL human epidermal growth factor (EGF). … A number of patients had a history ofcoronary artery disease (75 %) …

Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal …

www.ncbi.nlm.nih.gov/…/PMC27965…

National Center for Biotechnology Information

by S Belmadani – ‎2009 – ‎Cited by 20 – ‎Related articles

Apr 2, 2009 – EGF increased MSCs adhesion to CECs, and increased …. over the left anterior descending coronary artery (LAD), as described by Toyota et al. ….. Leri A, Anversa P. Bone marrow cells regenerate infarcted myocardium.

Rebuilding the Damaged HeartThe Potential of Cytokines and Growth …

content.onlinejacc.org/article.aspx?…

Journal of the American College of Cardiology

by N Beohar – ‎2010 – ‎Cited by 76 – ‎Related articles

Oct 12, 2010 – The recruited cells contribute to myocardial regeneration both as a structural … recombinant human vascular endothelial growth factor … kinase with Ig-like loops and Epidermal growth factor homology domains-2; VEGF … FGF in patients with coronary artery disease (CAD) and medically refractory angina.

Possible Local Stem Cells Activation by Microcurrent Application in …

www.ncbi.nlm.nih.gov/…/PMC42499…

National Center for Biotechnology Information

by MB Zickri – ‎2014 – ‎Related articles

Jul 25, 2014 – Keywords: Skeletal muscle, Injury, Microcurrent, Satellite cells … Regeneration therapy device which produces a microcurrent range was ….. the decidual spiral artery wall during early post-implantation mouse pregnancy. … Zhao X, Huang L. Cardiac stem cells: A promising treatment option for heart failure.

Ultra-low microcurrent in the management of diabetes mellitus … – NCBI

www.ncbi.nlm.nih.gov/…/PMC27927…

National Center for Biotechnology Information

by BY Lee – ‎2010 – ‎Cited by 31 – ‎Related articles

Dec 6, 2009 – In an earlier work, The Electro Pressure Regeneration Therapy (EPRT) …. left ventricular failure, renal failure and a history of a coronary artery …

Harnessing developmental processes for vascular engineering and …

www.ncbi.nlm.nih.gov/…/PMC4197623/ National Center for Biotechnology Information

by KM Park – ‎2014 – ‎Cited by 15 – ‎Related articles

Peripheral artery, cardiovascular, carotid artery, renal artery and venous … being applied to improve approaches for vascular engineering and regeneration. ….. I hydrogels using microfabrication, which allows the control of nutrients and oxygen …. PEG- and collagen-based hydrogel materials to treatcardiac infarction (Chiu .

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Study of vascular injuries using endothelial denudation model and the …

www.ajtr.org/files/AJTR1103003.pdf

by CK Sun – ‎2011 – ‎Cited by 5 – ‎Related articles

May 15, 2011 – tion and coronary artery bypass grafting for re- storing myocardial …. VEGF, Flt-1,eNOS, VEGFR2, flk-1/KDR, phospholipase. Cγ1, IP3, Ca2+, NOS, Ang-1 …. sue regeneration after ESWT as reported previ- ously [45], although …