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KidneyCell is a startup within the Leonhardt Ventures Cal-X Stars Business Accelerator and Leonhardt’s Launchpads Utah focused on kidney regeneration.
The company utilizes bioelectric stimulation to control release of specific proteins on demand for specific regenerative purposes in sequence:
1. SDF-1 (stem cell homing factor – recruits a persons own stem cells to stimulated tissues).
2. VEGF (for new blood vessel growth).
3 IGF-1 (for DNA repair at the nucleus level).
4. Follistatin (for muscle and tissue regeneration).
5. RANKL (for demineralization and tissue loosening when needed).
6. Hepatocyte Growth Factor (tissue regeneration)
7. eNOS (for dilating blood vessels for increasing flow).
8. Tropoelastin (increases elasticity of any tissues such as skin, arteries, aorta, heart and promotes healing of wounds).
9. Activin A + B
10. EGF Epidermal Growth Factor (regeneration)
In extreme cases we combine our regeneration microstimulator with an implantable, programmable, re-fillable stem cell/growth factor micro pump.
In cases of kidney cancer we have special signals to stop tumor cell division and blood supply followed by the above regeneration protocol.
KidneyCell
Leonhardt Ventures’ Cal-X Stars Business Accelerator, Inc.
1531 6th Street, Unit 401
Santa Monica, CA 90401
Tel: 310 310 2534
Leonhardt’s Launchpads Utah
489 E, 400 South, Unit 116
Salt Lake City, UT 84111
email: hleonhardt@aol.com
Contact: Howard J. Leonhardt
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[av_toggle title=’Related Scientific Articles:’ tags=”]
Trophic Factors from Tissue Stem Cells for Renal Regeneration
www.hindawi.com/journals/sci/aa/537204/
by K Tsuji – Cited by 3 – Related articles
Jan 9, 2015 – However, regarding renal regeneration, stem cells are discussed to … paracrine including interleukin-6 (IL-6), VEGF, SDF–1, and IGF-1 [24].
Role of Growth Factors in Regulation of Renal Growth – Annual Reviews
www.annualreviews.org/doi/pdf/10…/annurev.ph.55.030193.001513
Annual Reviews
by MR Hammerman – 1993 – Cited by 43 – Related articles
KEY WORDS: epidermal growth factor, fibroblast growth factor, hepatocyte growth … processes ofkidney growth, regulation of renal function, repair following.
SDF-1
Role of SDF-1 as a regulatory chemokine in renal regeneration after …
www.sciencedirect.com/science/article/pii/S2157171615310194
ScienceDirect
by FE Togel – 2011 – Cited by 9 – Related articles
Dec 16, 2015 – Both the homing of hematopoietic stem cells (HSCs) to the bone marrow and their engraftment in recipients of bone marrow transplants are …
Upregulation of Stromal Cell–Derived Factor 1 (SDF-1) is Associated …
www.ncbi.nlm.nih.gov/…/PMC42577…
National Center for Biotechnology Information
by X Wan – 2014 – Cited by 3 – Related articles
Dec 5, 2014 – Kidney repair is comprised of surviving epithelial cells that adapt to the loss … In a model of I/R injury induced renal neovascularization, SDF–1 …
SDF-1 activates papillary label-retaining cells during kidney repair …
www.jove.com/…/sdf–1-activates-papillary-label-ret…
Journal of Visualized Experiments
Jun 7, 2014 – The data indicate that the SDF–1/Cxcr4 axis is a critical regulator of papillary LRC activation following transient kidney injury and during organ …
IGF-1
Search Results
`The growth hormone–insulin-like growth factor axis in kidney re …
ndt.oxfordjournals.org/content/14/8/1853.long
by MR Hammerman – 1999 – Cited by 34 – Related articles
Recovery is dependent on the ability of the tubular cells to regenerate and … If IGF I were protective for the kidney, one might expect that its administration to rats …
Insulin-like growth factor-1 enhances epidermal growth factor receptor …
www.ncbi.nlm.nih.gov/pubmed/7539476 National Center for Biotechnology Information
by JJ Lin – 1995 – Cited by 45 – Related articles
… factor receptor activation and renal tubular cell regeneration in postischemic … Growth factors such as insulin-like growth factor-1 (IGF–1), epidermal growth …
Insulin-like growth factors and kidney disease. – NCBI
www.ncbi.nlm.nih.gov/…/25151409
National Center for Biotechnology Information
by LA Bach – 2015 – Cited by 15 – Related articles
Aug 21, 2014 – Insulin-like growth factors (IGF–1 and IGF-2) are necessary for … IGFs have a potential role in enhancing stem cell repair of kidney injury.
Effects of growth hormone and insulin-like growth factor I on renal …
www.ncbi.nlm.nih.gov/…/9255221
National Center for Biotechnology Information
by MR Hammerman – 1997 – Cited by 19 – Related articles
(1)Department of Internal Medicine, Washington University School of Medicine, St. Louis, … growth, and function and participate in the repair processes after renal injury. … Insulin-like growth factor I (IGF-I) accelerates the restoration of kidney …
Enhanced renoprotective effect of IGF-1 modified human umbilical …
www.nature.com › Scientific Reports › Articles Nature
by P Liu – 2016 – Cited by 1
Feb 2, 2016 – Our results indicated that the IGF–1 overexpression could enhance the … and anti-apoptosis capacity to repair kidney tissues in the rat model of …
Insulin-Like Growth Factor-1 Sustains Stem Cell–Mediated Renal Repair
jasn.asnjournals.org/content/18/11/2921.full
by B Imberti – 2007 – Cited by 224 – Related articles
These findings indicate that MSC exert beneficial effects on tubular cell repair in acute kidney injury by producing the mitogenic and pro-survival factor IGF–1.
Can hgh regenerate kidney cells? – Steroid.com Forums
forums.steroid.com › … › IGF-1 LR3, HGH, and INSULIN QUESTIONS
Jan 20, 2009 – … IGF–1 LR3, HGH, and INSULIN QUESTIONS; Can hgh regenerate … He said I either needed to start dialysis or have a kidney transplant.
EGF – Epidermal Growth Factor
Epidermal growth factor enhances renal tubule cell regeneration and …
www.ncbi.nlm.nih.gov/…/PMC30405…
National Center for Biotechnology Information
by HD Humes – 1989 – Cited by 344 – Related articles
Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure.
Hepatocyte Growth Factor
Hepatocyte growth factor in renal regeneration, renal disease and …
www.ncbi.nlm.nih.gov/…/10926176
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by K Matsumoto – 2000 – Cited by 64 – Related articles
Curr Opin Nephrol Hypertens. 2000 Jul;9(4):395-402. Hepatocyte growth factor in renal regeneration, renal disease and potential therapeutics. Matsumoto K(1) …
Hepatocyte growth factor in renal failure: promise and reality. – NCBI
www.ncbi.nlm.nih.gov/…/10760078
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by GA Vargas – 2000 – Cited by 118 – Related articles
In the case of Prometheus, we can now suppose that his amazing hepatic regeneration was caused by a peptide growth factor called hepatocyte growth factor …
Hepatocyte growth factor: renotropic role and potential therapeutics for …
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by K Matsumoto – 2001 – Cited by 377 – Related articles
Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases. … Locally and systemically increased HGF supports renal regeneration, …
Hepatocyte growth factor in kidney fibrosis: therapeutic potential and …
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National Center for Biotechnology Information
by Y Liu – 2004 – Cited by 267 – Related articles
Hepatocyte growth factor (HGF) is a pleiotropic factor that plays an imperative role in tubular repairand regeneration after acute renal injury. Growing evidence ..
Activin
Activin-like kinase 3 is important for kidney regeneration and … – NCBI
www.ncbi.nlm.nih.gov/…/22306733
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by H Sugimoto – 2012 – Cited by 89 – Related articles
Nat Med. 2012 Feb 5;18(3):396-404. doi: 10.1038/nm.2629. Activin-like kinase 3 is important forkidney regeneration and reversal of fibrosis. Sugimoto H(1) .
Follistatin
Involvement of the activin-follistatin system in tubular regeneration …
www.ncbi.nlm.nih.gov/…/11461941
National Center for Biotechnology Information
by A Maeshima – 2001 – Cited by 63 – Related articles
This study was conducted to investigate the involvement of the activin-follistatin system in renal regeneration after ischemic injury. Expression of mRNA for the …
The role of the activin-follistatin system in the developmental … – NCBI
www.ncbi.nlm.nih.gov/…/11544099 National Center for Biotechnology Information
by A Maeshima – 2001 – Cited by 32 – Related articles
Cytokine Growth Factor Rev. 2001 Dec;12(4):289-98. The role of the activin-follistatin system in the developmental and regeneration processes of the kidney.
Stem Cells
Stem cells in kidney regeneration. – NCBI
www.ncbi.nlm.nih.gov/…/22963572
National Center for Biotechnology Information
by S Yokote – 2012 – Cited by 5 – Related articles
Curr Med Chem. 2012;19(35):6009-17. Stem cells in kidney regeneration. Yokote S(1), Yokoo T. Author information: (1)Division of Nephrology and Hypertension …
Scientists Report Breakthrough in Growing Kidneys from Stem Cells
www.healthline.com › Healthline News
Healthline Networks
Sep 23, 2015 – Scientists Report Breakthrough in Growing Kidneys from Stem Cells … “Several groups, including us, have reported regeneration of kidney, …
Regrow or Repair: Potential Regenerative Therapies for the Kidney
jasn.asnjournals.org/content/17/9/2390.full
by MH Little – 2006 – Cited by 129 – Related articles
Other in situ possibilities include the recruitment of stem cells to the kidney to elicit repair and the induction of dedifferentiation of resident renal cells. Whereas …
Electrical Stimulation
Acupuncture with electrical stimulation may treat … – Medical Xpress
medicalxpress.com › Diseases, Conditions, Syndromes
Aug 14, 2014 – Acupuncture with electrical stimulation may treat muscle atrophy caused … result ofkidney and other diseases, according to a study appearing in an … The researchers found that the treatment improved muscle regeneration in …
Acupuncture plus Low-Frequency Electrical Stimulation (Acu-LFES …
journals.plos.org/plosone/article?id=10.1371/journal.pone.0134511
by Z Su – 2015 – Cited by 4 – Related articles
Jul 31, 2015 – Muscle regeneration capacity was significantly increased by Acu-LFES. … (2015) Acupuncture plus Low-Frequency Electrical Stimulation …… Exercise ameliorates chronic kidneydisease-induced defects in muscle protein ..
Adult kidneys constantly grow, remodel themselves, study finds | News …
Jun 19, 2014 – “These are basic findings that have direct implications for kidney disease and kidney regeneration,” said Yuval Rinkevich, PhD, the lead author …
Researchers make step towards kidney regeneration by developing …
Jun 7, 2016 – Researchers have established methods for culturing kidney progenitor cells in vitro that maintain their ability to form the glomerulus.
Need A New Kidney? Let’s Regenerate One! – Asian Scientist Magazine
www.asianscientist.com/…/in…/kidney-progenitor-cell-regeneration-tissue-engineerin…
Jun 15, 2016 – Under the correct conditions, kidney progenitor cells can be induced to produce more glomeruli and tubules, the building blocks of the kidney.
Expansion of kidney progenitor cells toward regenerative medicine …
Jun 6, 2016 – The kidney is a difficult organ to regenerate. However, in a big step forward for kidney regeneration research, a collaboration between scientists …
Human amniotic fluid stem cell preconditioning improves their regenerative potential.
Abstract
- PMID:
- 22066606
- PMCID:
- PMC3396139
- DOI:
- 10.1089/scd.2011.0333
- [Indexed for MEDLINE]
Stem cells derived from human amniotic fluid contribute to acute kidney injury recovery.
Abstract
- PMID:
- 20724594
- PMCID:
- PMC2947295
- DOI:
- 10.2353/ajpath.2010.091245
- [Indexed for MEDLINE]
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