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The HairCell Hair Regeneration Protocol
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HairCell is a startup in the Leonhardt Ventures’s Cal-X Stars 5 Year Business Accelerator and Leonhardt’s Launchpads NorCal @ University of Northern California Science & Technology Innovation Center focused on hair regeneration.
The HairCell technology platform is based on the Leonhardt et. al patent and patent pending portfolio of technologies for a regeneration micro stimulator that controls expressions of specific proteins on demand for specific regenerative purposes in sequence.
1. SDF-1 (stem cell homing factor – recruits a persons own stem cells to stimulated tissues).
2. VEGF (for new blood vessel growth).
3 IGF-1 (for DNA repair at the nucleus level).
4. Follistatin (for muscle and tissue regeneration).
5. RANKL (for demineralization and tissue loosening when needed).
6. Hepatocyte Growth Factor (tissue regeneration)
7. eNOS (for dilating blood vessels for increasing flow).
8. Tropoelastin (increases elasticity of any tissues such as skin, arteries, aorta, heart and promotes healing of wounds).
The stimulation signals are delivered non-invasively via a specially designed electrode equipped helmet which as originally designed for brain EEG analysis. The micro stimulator is connected to this helmet and lies just behind the ear.
For very severe difficult cases and for more rapid hair regeneration we combine our micro stimulator with a stem cell/growth factor micro pump www.fluidsynchrony.com in our most advanced model which will be connected to a special device with low depth penetration hollow electro-acupuncture needles.
The company is also working on a wireless version.
References Related Articles Supporting Leonhardt Patented and Patent Pending Signals for Hair Regeneration: VEGF : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC199257/
IGF – 1: http://www.hairloss-research.org/UpdateIGF10-11.html
Follistatin: http://www.ncbi.nlm.nih.gov/pubmed/22052313
Tropoelastin: https://www.proteingenomics.com/haircare.html
SDF – 1: https://en.wikipedia.org/wiki/Stromal_cell-derived_factor_1
HGF: http://www.ncbi.nlm.nih.gov/pubmed/11164712
Contacts:
Media Relations: Brian Hardy @ brian@fizzpopmedia.com
Contact Company:
Derek Kahn, President @ email dakone@comcast.net
HairCell
@ Leonhardt’s Launchpads NorCal
University of Northern California Science & Technology Innovation Center
1300 Valley House Dr, Suite # 100-27
Rohnert Park, CA 94928
(707) 664-6365
Senior Advisors: Dr. Y. King Liu @ University of Northern California Science & Technology Innovation Center – YKingLiu@uncm.edu + Paul Norman, Napa, California – email: pnrmn@comcast.net + Dr. John Marchetto, Weston, Florida – email: marchetto425@bellsouth.net
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SDF-1 (stem cell homing factor)
Bioengineering the Hair Follicle – NCBI – National Institutes of Health
www.ncbi.nlm.nih.gov/…
Low current electrical stimulation upregulates cytokine expression in …
www.ncbi.nlm.nih.gov/…
Cure for baldness? Stem cells bring hope – Medical News Today
www.medicalnewstoday.com/articles/271898.php
Shrinking Stem Cells Are the Real Reason for Hair Loss | TIME
time.com/4209749/hair–loss–stem–cells/
Studies indicate it’s possible to use stem cells to cure baldness
www.cnbc.com/…/studies-indicate-its-possible-to-use-stem–cells-to…
Follistatin
A role of follistatin in the control of hair follicle morphogenesis
www.fasebj.org/content/early/…/fj.02-0247fje.full.pd…
[PDF]Nouricel Hair Re-Growth & Neogenesis – ZacksInvest
https://www.zacksinvest.com/…/HSC%20Application%20Overview.pdf
Regenerative Hair Waves in Aging Mice and Extra-Follicular …
www.sciencedirect.com/science/…/S0022202X15369372
The Thinning Top: Why Old People Have Less Hair – Nature
www.nature.com/jid/journal/v134/n8/pdf/jid2014172a.pdf?WT…
http://www.des-company.com/wp-content/uploads/2014/05/Zimber-et-al-2011.pdf
http://www.ncbi.nlm.nih.gov/pubmed/22052313
IGF-1
Exogenous IGF-1 promotes hair growth by stimulating cell proliferation …
www.sciencedirect.com/science/…/S1096637414000239
IGF-1 | Theory | JAPAN HAIR GROWTH CONSULTANTS
www.jhgc.com.sg/theory/igf–1/index.html
Insulin-like Growth Factor 1 (IGF-1) | The End of Hair Loss and Balding …
www.hairlosscure2020.com/insulin-like-growth-factor-1–igf–1/
LEAKED: Break-through Hair Loss Treatment with Unexpected …
www.nicehair.org/breakthrough-hair–loss-cure-based-on-3-combined-gr…
http://www.ncbi.nlm.nih.gov/pubmed/10673454
HGF
Hepatocyte growth factor (HGF) activator expressed in hair follicles is …
www.ncbi.nlm.nih.gov/…
Hair Regeneration Treatment Using Adipose-Derived Stem Cell …
www.ncbi.nlm.nih.gov/…
[PDF]The Latest Advance in Hair Regeneration Therapy Using Proteins …
www.orangecountyhairrestoration.org/…/ADSC-hair–restoration.pdf
Reversing Age-Related Hair Loss and Restoring Healthy Hair Growth …
nutritionreview.org/…/reversing-age-related-hair–loss-and-restoring-healt…
http://www.sciencedirect.com/science/article/pii/S0923181100001249
https://www.youtube.com/watch?v=aWK6qJFvWoM
http://www.ncbi.nlm.nih.gov/pubmed/10674388
http://www.fasebj.org/content/14/2/319.full
eNOS and VEGF
Interesting study about prolactin, VEGF and … – Regrowth.com
www.regrowth.com › Hair Loss Forums › General Hair Loss
Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF …
https://www.spandidos-publications.com/ijmm/36/3/685
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC199257/
http://www.hairloss-reversible.com/control-of-hair-growth-by-a-growth-factor-protein/
http://www.svijet-kose.com/dokumenti/Serum-vegf.pdf
https://www.sciencedaily.com/releases/2001/02/010215074636.htm
Activin
Activin B Promotes Initiation and Development of Hair … – Karger
https://www.karger.com/Article/Pdf/356304
Activin B promotes initiation and development of hair follicles in mice.
www.ncbi.nlm.nih.gov/…
TROPOELASTIN
Protein Genomics – Elastatropin® in Scalp & Hair Conditioning
https://www.proteingenomics.com/haircare.html
www.keracyte.com/index.php/site/page?view=whatIsElastin
Multiple Protein Expressions
http://www.orangecountyhairrestoration.org/webdocuments/ADSC-hair-restoration.pdf
http://www.indjst.org/index.php/indjst/article/viewFile/80263/62051
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INVENTION TITLE
A method and apparatus for producing hair growth stimulation using bioelectric energy, topical compositions, stem cell/growth factor micro infusions and combinations thereof. By using bioelectric signaling resulting from specific protein expressions and their cellular responses to exposure to specific micro voltages.
BACKGROUND OF THE INVENTION
Problem Solved: Many people lose hair as they age. Thin hair causes loss of self-esteem.
Other methods and devices at best increase hair coverage by 10%.
Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.
DETAILED DESCRIPTION OF THE INVENTION
As stated above, many people lose hair as they age. Thin hair causes loss of self-esteem. The invention claimed here solves this problem.
Our devices utilizes specific bioelectric signals to control release of 10 key hair regeneration proteins and for severe cases is combined with a stem cell/growth factor micro infusion pump to regenerate a full head of hair.
The claimed invention differs from what currently exists. No other product delivers a full complete combination of growth factors and stem cells necessary for complete and full hair regeneration.
This invention is an improvement on what currently exists. No other product delivers a full complete combination of growth factors and stem cells necessary for complete and full hair regeneration.
Prior art fails to address all the mechanisms necessary for complete hair regeneration. Most current treatments have nowhere near the volume of active agent necessary to regenerate a full head of thick hair.
Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.
Also, it can produce Hair regeneration. Hair removal. Skin regeneration.
The Version of The Invention Discussed Here Includes:
- Brain Electroacupuncture Cap
- Micro regeneration stimulator and connecting leads
- Micro infusion pump
- Bioelectric signal program SDF-1 = Stem Cell Homing Factor
- Bioelectric signal program IGF-1
- Bioelectric signal program HGF
- Bioelectric signal program EGF
- Bioelectric signal program Follistatin
- Bioelectric signal program Tropoelastin
- Bioelectric signal program eNOS
- Bioelectric signal program VEGF
- Bioelectric signal program Activin A + B
- Hair regeneration cocktail 15 component composition
- Bioelectric signal for cell proliferation
- Bioelectric signal to control differentiation
Relationship Between The Components:
Brain electroacupuncture cap (1) is placed on head of patient. (2) micro regeneration stimulator is connected to brain cap (1). Micro infusion pump (3) is connected to brain electroacupuncture cap. Micro stimulator runs through a program releases 10 specific proteins for specific purposes all of which work together for complete hair regeneration. In severe cases a micro pump is filled with the HC-15 fifteen component hair regeneration cocktail comprising three types of stem cells, growth factors, nutrient hydrogel, scalp matrix and Micro RNAS as well as known topical solutions for hair regeneration. 12. The method of claim 1 where said bioelectric signal produces eNOS – Alternating high-frequency (HF) and medium-frequency signals (MF) – Symmetric, biphasic, trapezoid pulses, with 400-µs pulse duration and 1.5/1-s ramp-up/ramp-down duration, respectively. HF consisted of 75 Hz pulses with 6 s on–21 s off for 15 minutes. MF consisted of 45 Hz pulses with 5 s on–12 s off for 15 minutes. Followed by stimulation duration set as 20 min for both 1 Hz and 20 Hz stimulations. For 1 Hz stimulation, stimulation was applied for 9 sec, followed by a 1 sec silent period, a total of 1080 stimulations for 20 min. For 20 Hz stimulation, stimulation was applied for 2 sec, followed by silent period for 28 sec, a total of 1600 stimulations for 20 min.
- The method of claim 1 where said bioelectric signal produces Activin A – 6mv at 150 HZ Monophasic square wave pulse 0.1 ms in duration current of 15 mA for 15 minutes.
How The Invention Works:
The micro hair regeneration stimulator may be used as a standalone. Results are accelerated and enhanced with the addition of the micro infusion pump that is re-filled daily, weekly or monthly. 14. Method of claims 1 to 13 in sequence order of VEGF, eNOS, SDF-1, Proliferation, VEGF, eNOS, HGF, IGF-1, Follistatin, Differentiation, Tropolastin, Follistatin, IGF-1, HGF, SDF-1 and repeated.
- Method of claim 1 where bioelectric signal causes controlled expression of FGF.
- Method of claim 1 where bioelectric signal causes controlled expression of EGF
How To Make The Invention:
The brain cap is adapted from EEG monitoring caps and electro acupuncture needles. The micro stimulator is obtained from an OEM supplier of heart pacemakers. The software is programmed into the stimulator with a standard programmer. The micro pump is obtained from an OEM supplier that makes pumps for drug infusion.
The micro regeneration stimulator is essential. The brain cap is optional. You can use tape electrodes or standard electro acupuncture needles instead OR the signals can be transmitted by a wireless light like device. The micro infusion pump is optional for severe cases or for accelerating results.
- The method of claim 1 where said bioelectric signal produces – stem cell differentiation signals – (Leonhardt Signals) – 200 picoamps for 10 seconds for 1 hr + the pulse has an amplitude of 5 volts and a width of 0.5 milliseconds for 1 hr
- The method of claim 1 where said bioelectric signal produces Follistatin – (muscle growth) production signal (Genovese + Leonhardt) – 10V @ 50 HZ and 100 HZ for 12 hrs each
- The method of claim 1 where said bioelectric signal produces HGF – Hepatocyte growth factor (arrhythmia reduction) signal (Genovese + Leonhardt) – 3.5V stimulation in 10 second bursts, 1 burst every 30 seconds @ frequency 50 HZ
- The method of claim 1 where said bioelectric signal produces IGF-1 (Genovese + Leonhardt) – 3mv with electric frequency of 22 Hz, and electric current of 1 mA for 15 minutes and 3ma for 15 minutes
- The method of claim 1 where said bioelectric signal produces Tropoelastin (Genovese + Leonhardt) – 0.06?V with 50Z alternating electrical field and electric current of 1ma for 15 minutes and 3ma for 15 minutes
- The method of claim 1 where said bioelectric signal produces RANKL nuclear factor-kappa B (NF-?B) ligand (Genovese + Leonhardt + Marchetto) – 3MV at 2/100 Hz alternating frequency with current of 3ma followed by 15 Hz, 1 Gauss EM field, consisting of 5-millisecond bursts with 5-microsecond pulses followed by 200-µs pulse duration @ 30 Hz and with current amplitude of 140 mA.
- The method of claim 1 where said bioelectric signal produces eNOS – Alternating high-frequency (HF) and medium-frequency signals (MF) – Symmetric, biphasic, trapezoid pulses, with 400-µs pulse duration and 1.5/1-s ramp-up/ramp-down duration, respectively. HF consisted of 75 Hz pulses with 6 s on–21 s off for 15 minutes. MF consisted of 45 Hz pulses with 5 s on–12 s off for 15 minutes. Followed by stimulation duration set as 20 min for both 1 Hz and 20 Hz stimulations. For 1 Hz stimulation, stimulation was applied
How To Use The Invention:
The brain cap is connected to the stimulator and pump and treatment is 40 minutes 3 times a week for 8 to 36 weeks as needed. Claims (16)
- A method for stimulating hair growth, comprising: exposing a hair growth structure to a source of narrow band of bioelectric signals, without having applied a drug, cosmeceutical, and/or chromophore to the hair growth structure;
bioelectrical signal controlled protein release to promote hair growth by maintaining the exposure of the hair growth structure to the source of narrowband of bioelectric signals for protein expression for a clinically effective duration and at a clinically effective depth to stimulate hair growth without causing skin ablation.
- The method of claim 1 wherein said source of narrowband bioelectric signals are delivered by any one of these methods; wireless transmission, electro-acupuncture needles, conductive patches doped with hair growth promoting drugs and proteins, a conduction signal helmet or cap, a metal hair scalp tickler or any combination thereof.
- The method of claim 1 where said bioelectric signal produces vascular endothelial growth for factor release VEGF – to promote hair growth and blood vessel sprouting growth 0.1V applied at a frequency of 50 Hz. 4. The method of claim 1 where said bioelectric signal produces SDF-1 – Stem cell recruiting signal (the Leonhardt Signal) – 30 pulses per second with a voltage of 3.5 mV, and successively alternating currents of 700 to 1500 picoamps for one minute, and again with 700 to 1500 picoamps for one minute + stimulated with current of 0.25 mA, pulse duration of 40 pulses/s, pulse width of 100 µs, and frequency of 100 Hz. 5. The method of claim 1 where said bioelectric signal produces – stem cell proliferation signal (Leonhardt-Chachques) – 15 mV and a current of 500 picoamps at 70 pulses per minute for 3 hrs + 20 pulses per minute, a pulse amplitude of from 2.5-6 volts, and a pulse width of from 0.2-0.7 milliseconds for 3 hrs
Additionally: The micro stimulator + micro pump + regeneration composition + bioelectric signaling programming may be used to regenerate any tissue or organ.
Also, it can create: Hair regeneration. Hair removal. Skin regeneration.
ABSTRACT
A method and apparatus for producing hair growth stimulation using bioelectric energy, topical compositions, stem cell/growth factor micro infusions and combinations thereof. By using bioelectric signaling resulting from specific protein expressions and their cellular responses to exposure to specific micro voltages. Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.
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