Microcurrent Directed Stem Cell Repair of Aortic Aneursysms
Microcurrent energy signal waveform causes aortic tissue to release SDF-1 the universal stem cell homing signal which causes stem cells to migrate from a patients bone marrow, fat and circulating blood to the tissue where the signal energy is focused. After recruitment of stem cells the polarity of the signal is reversed and voltage dropped and this triggers differentiation of the cells into smooth muscle.
AortaCell utilizes non-invasive microcurrent energy for these applications (investigational use only at this time):
> Reinforces aortic necks to avoid expansion and thus allows for more secure long lasting anchor fixation of stent grafts.
> Can be used to totally repair a small aortic or cerebral aneurysm non-invasively.
> With various different transmission signals can be used to seal endoleaks.
AortaCell is based on adaptations and improvements of technology originally explained by Dr. Robert O. Becker in his landmark 1985 publication The Body Electric…
Robert Otto Becker (May 31, 1923 − May 14, 2008) was a U.S. orthopedic … show a direct current of electric charge which is measurable from their body surface.
AortaCell is developing two versions of our product (1) one wireless external and the other that delivers the energy signal more directly and at close range at the tip of an (2) endovascular catheter:
1. Wireless external energy system working in partnership with www.wetling.dk in Denmark. We completed a 47 patient study in Europe with this team in 2013 for treating diabetic foot ulcers which was published – http://www.calstockexchange.com/wp-content/uploads/2014/09/WMCS_International_Wound_Journal_Jan_2014.pdf
2. Endovascular catheter based system with deflecting tip and optical/conduction probe for more close hand direct delivery of the proper microcurrent energy signals to the target aortic tissue. Less risk of distortion of pure signal than the wireless external energy system described above.
Patented, patent pending or patent in process signals include….
1. Signal to cause stimulated tissue to release SDF-1 = stem cell homing signal.
2. Signal to cause stimulated tissue to release VEGF = blood vessel growing.
3. Signal to cause stem cells to differentiate into muscle.
4. Signal to cause stimulated tissue to release follistatin = key muscle building protein.
5. Signal to proliferate stem cells at a specific target location under control.
6. Signal to stop blood vessel feeding of the back of aneurysm or a tumor – anti-angiogenic.
We have more than a dozen other related patent applications in process.
AortaCell is focused on applying microcurrent via directing stem cells to repair aortic aneuyrsms.
How does it work? The microcurrent signal causes the weakened aortic wall tissue to release SDF-1, which is a stem cell homing signal, and stem cells than migrate from the patient’s own bone marrow, fat and circulating blood to the weakened area. After we have recruited enough repair cells we flip a switch on the microcurrent stimulator and the polarity is reversed and the voltage is dropped and we trigger the stem cells to form into smooth muscle. The end result is the previous thin aortic vessel wall is now thick strong and muscular with no risk of rupturing.
How may it be applied?
1. Total repair of small aortic aneurysms non-invasively by place the microcurrent signal generator above the area (outside the body like shinging a flashlight or how they do focal radiation therapy for cancer) to be treated. We may or may not have to place a negative electrode on the back of the patient.
2. Strengthening aortic necks to improve endoluminal stent graft long term sealing and to reduce risk of migration.
3. A different anti-angiogenic microcurrent signal may be used to non-invasively seal backflow collateral type endoleaks.
4. We can direct the microcurrent signal via an optical probe endovascular catheter to better ensure the pure right signal reaches the target aortic wall tissue for regeneration without the hinderance of calibrating for the fat, hair and other obstacles in the way of a pure to tissue signal with the non-invasive system. You may have seen John Simpson’s new startup is directing laser light up a post athrectomy catheter and PDA balloon to improves results of lower limb revascularization. We can do the same with our patented microcurrent signals which we believe will be more effective than laser light or ultrasound.
5. We can wrap a stent graft, or at least the proximal and distal necks, with a microcurrent bandage – like this one www.procellera.com. This will attract stem cells to graft material especially at the fixation sealing points.
6. We can coat graft material with an agent and then use the non-invasive microcurrent signaling to grow muscle up and down the graft material to strengthen and seal it. With this procedure you could reduce the entry profile of a stent graft with thinner materials and then build up the strength and sealing ability afterwards with non-invasive microcurrent treatments or by a 5FR optical probe microcurrent delivery catheter.
AortaCell TM = non-invasive microcurrent energy that in stage 1 causes a stem cell homing signal protein (SDF-1) to be released from stimulated aortic aneurysmal tissue (stem cells home to this focal stimulated tissue coming from the patients own bone marrow, fat tissue and circulating blood) and in stage 2 (reversed polarity and lower voltage) differentiates those recruited stem cells into smooth muscle thus strengthening the aortic wall back to healthy non-aneurysmal tissue sufficiently strong to eliminate continued expansion of the aneurysm. This method follows exactly the natural tissue regeneration method found in nature in all animals.
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