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Stem Cells in Teeth
The tooth is nature’s ‘safe’ for your family’s unique stem cells
While stem cells can be found in most tissues of the body, they are usually buried deep, are few in number and are similar in appearance to surrounding cells. With the discovery of stem cells in teeth, an accessible and available source of stem cells has been identified.
The tooth is nature’s “safe” for these valuable stem cells, and there is an abundance of these cells in baby teeth, wisdom teeth and permanent teeth – Tooth Eligibility Criteria. The stem cells contained within teeth are capable of replicating themselves and can be readily recovered at the time of a planned dental procedure.
Living stem cells found within extracted teeth were routinely discarded every day, but now, with the knowledge from recent medical research, DentaCell gives you the opportunity to save these cells for future use in developing medical treatments for your family.
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Aside from being the most convenient stem cells to access, dental stem cells have significant medical benefits in the development of new medical therapies. Using one’s own stem cells for medical treatment means a much lower risk of rejection by the body and decreases the need for powerful drugs that weaken the immune system, both of which are negative but typical realities that come into play when tissues or cells from a donor are used to treat patients.
Further, the stem cells from teeth have been observed in research studies to be among the most powerful stem cells in the human body. Stem cells from teeth replicate at a faster rate and for a longer period of time than do stem cells harvested from other tissues of the body.
Stem cells in the human body age over time and their regenerative abilities slow down later in life. The earlier in life that your family’s stem cells are secured, the more valuable they will be when they are needed most.
DentaCell is moving forward step by step with the co-development of these products for dental gum healing…
1. PosiFect dental gum healing strips. – Click for more info (PosiFect U.S. 510K is pending -CE Mark received)
2. Wetling Health wireless energy dental gum healing device.
3. MyoStim Micocurrent stimulator wire based applied with dental mouth tray with conductive and healing hydrogel (note we have been researching nutrient healing hydrogels since the early 1990’s)
4. Bioheart Adipose Cell Harvesting Kits to make stem cell injections combined with scaffolding collagen matrix applied to grow back receding dental gums combined with healing hydrogel and micorcurrent stimulation from any one of the three above mentioned devices ie; Procellera, Wetling or MyoStim Microcurrent.
5. TissueGen Microcurrent electroacupuncture system.
DentaCell – Tissue Banking Stem Cell Expansion Service
In contract partnership with Bioheart, Inc. of Sunrise, Florida
Tooth tissue banking is the storing of dental stem cells that have the ability to regenerate into various cell types. When your child’s tooth or your own tooth falls out or is extracted, dental stem cells are harvested from the dental pulp within the tooth. Baby teeth and wisdom teeth are rich in dental stem cells. These cells within the pulp are a valuable source of highly regenerative stem cells. These dental stem cells are preserved indefinitely by being cryogenically frozen.
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Banking dental stem cells gives you the ability to take advantage of stem cell therapies of today and those that emerge in the future.
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The DentaCell team has more experience working with stem cell therapies than any other dental tissue banking service in the USA. The Founders previously invented the first stem cell delivery catheter in the 1988 (patented in 1997). Developed the first stem cell harvesting system from adipose tissue – 1994. Completed the first non-surgical stem cell regeneration of damaged heart tissue – 2001. Was the first in the world to gain FDA approval to conduct Phase I and II/III stem cell and stem cell gene therapy clinical trials for treating heart damage (2003 2007 2009 2010). The DentaCell contract tissue banking and stem cell expansion facility with Bioheart, Inc. a public company founded by the same founders of DentaCell in Sunrise, Florida has been cGMP certified since 1989 (World Medical Mfg. Corp.) for medical implant manufacturing, since 2001 for stem cell expansion and since 2013 for tissue banking. See References below. Bioheart, Inc. has spent more than $140 million to develop the safety of stem cell processing, expansion storage, shipment, delivery and handling since 1999.
Both DentaCell and Bioheart, Inc. are supported by the Leonhardt Ventures’ Cal-X Stars Accelerator Scientific Advisory Board made up of over 35 leading stem cell researchers –http://calxstars.com/scientific-advisory-board/
Bioheart Receives Validated FDA Registration for Tissue
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At DentaCell we provide the best dental stem cell storage in the industry at the most affordable price, so that every family can take advantage of advancements in medicine. Ask us about our Family Plans that are available as well.
Processing Fee (Lab, Harvesting Cells, Viability): $375
First Year Storage: $115
Total First Year: $490
Annual Storage: $115
Full Payment: $490
2 month payment plan: $245/month
4 month payment plan: $123/month
Long Term Discounted Storage Plans
5 year storage: $499 (Savings of $76)
10 year storage: $799 (Savings of $351)
20 year storage: $1399 (Savings of $901)
* When Stem cells are needed in the future, DentaCell will multiply stem cells at no cost to you, unlike our competitors.
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Efficacy of electrical neuromuscular stimulation in the treatment of chronic periodontities
Catheter-Based Intramyocardial Injection of Autologous
Patent US5312380 – Endothelial cell procurement
Patent US5693029 – Pro-cell intra-cavity therapeutic agent
Bioheart, Inc. Expands Clinical Trials of Adult Myogenic
Fifteen Cell Therapies/Stem Cell Therapies in Phase III
Final Data From the Bioheart Seismic Trial Suggest Safety
Leonhardt Increases Stake in Bioheart, Inc.
Leading Experts Endorse Bioheart’s Muscle Stem Cell
Bioheart Inc. Announces Positive Results in the MARVEL
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What are dental pulp stem cells?
Dental pulp is the soft living tissue inside a tooth. Stem cells are found inside the dental pulp. Dental pulp stem cells retain the ability to renew themselves by dividing and can change into specialized cells.
Are these cells currently being used for treatments?
Dental pulp stem cells, are being used only in laboratory settings at this time. While mesenchymal (MSC) cells are currently used in procedures such as bone marrow transplants, MSC cells from dental pulp are not yet being used for medical treatments.
What types of cells can MSC cells become?
- Cardio Myocytes which have the potential to repair damaged cardiac tissue following a heart attack.
- Myocytes which have the potential to repair muscle.
- Osteocytes which have the potential to generate bone.
- Chondrocytes which have the potential to generate cartilage.
- Neuronal which have the potential to generate nerve and brain tissue.
- Adipocytes which have the potential to generate fat tissue.
When were dental pulp stem cells first identified?
Stem cells in dental pulp were discovered in 2000 by Dr. Songtao Shi, a dental researcher at the National Institute of Health (NIH). After verification that these cells were in fact
How long can stem cells be stored?
We know that stem cells from the late 1980’s are still viable. In fact, most research indicates that stem cells frozen through a slow-rate process and stored with liquid nitrogen are viable for an indefinite period.
Why is dental pulp a great source of stem cells?
Dental pulp stem cells can be harvested without controversy, in an inexpensive, non-invasive manner, unlike bone marrow and peripheral blood stem cell collection. These methods of stem cell recovery can be both painful and expensive. Umbilical cord blood, another source of stem cells, is a once in a lifetime opportunity at birth. Umbilical cord blood stem cells recovered are typically only used in disease treatment.
How is dental pulp collected?
Dental pulp collection is simple and poses no risk to the client. The tooth is either extracted or is harvested when it falls our naturally. Next a sterile transport medium is used to ship the tooth to the DentaCell contracted laboratory @ Bioheart, Inc. Sunrise, Florida. DentaCell removes the dental pulp from tooth, processes, and then cryogenically preserves and stores the stem cells.
Why do I need my dentist to harvest the teeth?
It is important to have your dentist or oral surgeon work with you to harvest a healthy tooth for preservation because with their help, you will be able to remove the tooth while a good blood supply is still present. If the tooth is allowed to fall out at home, there is less possibility of finding viable stem cells.
What happens if my child’s tooth is falling out early and my dentist has not received the kit?
We offer detailed instructions on collecting dental pulp without a collection kit on hand. These instructions can be faxed or e-mailed to your dentist. In an extreme emergency the tooth may be stored in milk in your refrigerator for a BRIEF period of time.
How is the kit picked up for delivery to DentaCells’ contract laboratory?
Our worldwide shipper picks up from the dental office as soon as the tooth is extracted. The kit is then immediately shipped to our laboratory and the tooth is processed promptly.
How do you prevent the stem cells from damage during the freezing process?
DentaCell’s processing technique via Bioheart, Inc. in Sunrise, Florida follows the FDA guidelines of minimal manipulation (until expansion is requested later). The stem cells are prepped for slow-freeze by using a cryoprotectant which prevents damage. The cryoprotectant is washed out of the stem cells in the thawing. Research has shown that this methodology is the most successful in terms of cell recovery.
How are the stem cells stored?
Stem cells are stored individually in a sealed cryo-container. The cryo-container is designed specifically for long-term cryogenic storage.
The container is coded and then placed in a jacketed vapor tank cooled by liquid nitrogen. This type of cooling method prevents all cross contamination.
One-hundred percent of the processed cells are preserved for you and nothing is withheld for our use, a procedure unique to DentaCell via Bioheart, Inc.
What systems are in place to protect stem cells during long-term storage?
Our cryogenic facility maintains multiple levels of security. This includes back up alarm systems, 24 hour on-call staff, 24 hour temperature monitoring, and a liquid nitrogen system with backup generators for un-interrupted power and backup systems that do not require electricity.
It is not known whether cells derived from stem cells retain their differentiation and morpho-functional properties after long-term cryopreservation. This information is of importance to evaluate their potential for long-term storage with a view to subsequent use in therapy. Here, we describe the morpho-functional properties of dental pulp stem cells (SBP-DPSCs), and of their differentiated osteoblasts, recovered after long-term cryopreservation. After storage for 2 years, we found that stem cells are still capable of differentiation, and that their differentiated cytotypes proliferate and produce woven bone tissue. In addition, cells still express all their respective surface antigens, confirming cellular integrity. In particular, SBP-DPSCs differentiated into pre-osteoblasts, showing diffuse positivity for ALP, BAP, RUNX-2, and calcein. Recovered osteoblasts expressed bone-specific markers and were easily recognizable ultrastructurally, with no alterations observed at this level. In addition, after in vivo transplantation, woven bone converted into a 3D lamellar bone type. Therefore, dental pulp stem cells and their osteoblast-derived cells can be long-term cryopreserved and may prove to be attractive for clinical applications.
[av_toggle title=’DentaCell Scientific Related Articles’ tags=”]
Microcurrent Stimulation: A Powerful Therapy
FuturePundit: Biotech Teeth And Gums Archives
New Research on Teeth Regeneration | SCENAR
Electro-acupuncture for Dentistry: Electroacupuncture
UNC School of Dentistry – Dental Acupuncture
Dental Stem Cell Preservation and the Dawning of Regenerative Oral Medicine
BIOHEART RECEIVES VALIDATED FDA REGISTRATION FOR TISSUE BANK ESTABLISHMENT
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Chris Rosgen is the Founder and President of Capital Market Relations, the publisher of capitalmarketreport.com and Associate Producer for American Health Journal on PBS.
At Capital Market Relations Chris has overseen capital market advisory to help companies with game-changing technology protect and build shareholder value. Stemming from his interest in “disruptive,” intellectual property almost two decades ago, Chris has dedicated his career to advancing new standards as a capital market luminary in science and technology. Chris provides expert commentary and broadcasts his latest research findings on Clear Channels IHeart Radio, The Business Talk Radio Network and Radio America.
At PBS American Health Journal, Chris is the Associate Producer and develops segment interviews with leading scientists and doctors developing new standards in healthcare and medical technology. The 30 minute show airs nationally in over 60 million households.
In addition Chris also serves as an Advisory Board Member to CalXStars Business Accelerator an incubator for private and pre-IPO companies.
He attended University of California Irvine, National Investor Relations Institute.
Chris Rosgen interviews, broadcasts in media and publishes capital market reports.
Founder, CEO & Capital Market Luminary
Capital Market Relations
Gary Abbott brings twenty years of capital markets experience to our company. He began his career as a sell-side analyst and gained widespread recognition for his research. His work has been cited in numerous financial and industry publications, including the Wall Street Journal, USA Today, Money Magazine and other media. Mr. Abbott also has experience in corporate finance and investor relations. He is currently a Managing Director in Merriman Capital’s Capital Markets Advisory Group where he works with C-level executives to support their needs with regard to capital markets, investor relations, and corporate development. Mr. Abbott holds a Bachelor of Science degree in General Business Administration from the University of Arizona and an MBA degree with a concentration in Finance from The Ohio State University.
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